%0杂志文章%A Evangelopoulos, Dimitris %A Chatzidiakou, Lia %A Walton, Heather %A Katsouyanni, klia %A Kelly, Frank J. %A Quint, Jennifer K. %A Jones, Roderic L. %A Barratt，伦敦个人暴露于空气污染与慢性阻塞性肺病患者呼吸健康J欧洲呼吸杂志先前的研究使用固定地点测量或有限数量的个人测量(通常针对一种污染物和短时间内)调查了空气污染对慢性阻塞性肺病(COPD)患者的影响。这些限制可能会引入偏差并扭曲流行病学关联，因为它们没有考虑到所有潜在的污染源或污染的时间变异性。我们使用了在精细时空尺度上测量的个人暴露于各种污染物的详细信息，以获得更可靠的影响估计。115名患者携带专门为该项目设计的个人监测器，以1分钟时间分辨率测量温度、二氧化氮(NO2)、臭氧(O3)、一氧化氮(NO)、一氧化碳(CO)和空气动力学直径<2.5和<10 μm的颗粒物，平均连续随访128天。每位患者每天记录呼吸道症状信息并测量呼气峰值流量(PEF)。肺科医生结合相关数据定义一个二元变量表示“恶化”。使用混合效应模型评估暴露-反应相关性。我们发现气态污染物与病人健康状况的恶化有关。我们观察到NO2、NO和CO在四分位数范围内增加时，加重几率分别增加16.4% (95% CI 8.6-24.6%)、9.4% (95% CI 5.4-13.6%)和7.6% (95% CI 3.0-12.4%)。咳嗽和痰也得到了类似的结果。 O3 was found to have adverse associations with PEF and breathlessness. No association was observed between particulate matter and any outcome.Our findings suggest that, when considering total personal exposure to air pollutants, mainly the gaseous pollutants affect COPD patients’ health.Significant adverse associations were found between the respiratory health of COPD patients and their personal exposure to gaseous pollutants measured using portable sensors over 6 months. No significant associations were found for particulate pollutants. https://bit.ly/3aqMT6O %U //www.qdcxjkg.com/content/erj/58/1/2003432.full.pdf