作者@article {Evangelopoulos2003432 = {Evangelopoulos, Dimitris Chatzidiakou, Lia和沃顿,希瑟和Katsouyanni Klea和凯利,弗兰克·j·和·昆特,珍妮弗·k·琼斯,罗德里克l . Barratt,本杰明},title ={个人暴露于空气污染和呼吸道健康的慢性阻塞性肺病患者在伦敦},体积= {58}= {1},以前的研究已经通过固定地点测量或有限数量的个人测量，调查了空气污染对慢性阻塞性肺病(COPD)患者的影响。188bet官网地址通常只针对一种污染物，而且时间很短。这些限制可能会造成偏见并歪曲流行病学的联系，因为它们没有考虑到所有潜在的污染源或污染的时间变异性。我们利用个人暴露于各种污染物的详细信息，在精细的时空尺度上测量，以获得更可靠的效果估计。一组115例患者平均随访了连续128天携带个人监控专门为这个项目设计,测量温度、二氧化氮(NO2),臭氧(O3)、一氧化氮(NO),一氧化碳(CO),和颗粒物空气动力学直径\ < 2.5和\ < 10μm(时间分辨率。每位患者记录每日呼吸症状信息并测量呼气峰值流量(PEF)。一位肺科医生结合相关数据定义了一个二元变量，表示{\textquotedblright}加剧。使用混合效应模型评估暴露反应相关性。我们发现，气体污染物与病人健康恶化有关。我们观察到NO2、NO和CO在四分位范围内增加的恶化几率分别增加了16.4\% (95\% CI 8.6{\textendash}24.6\%)、9.4\% (95\% CI 5.4{\textendash}13.6\%)和7.6\% (95\% CI 3.0{\textendash}12.4\%)。 Similar results were obtained for cough and sputum. O3 was found to have adverse associations with PEF and breathlessness. No association was observed between particulate matter and any outcome.Our findings suggest that, when considering total personal exposure to air pollutants, mainly the gaseous pollutants affect COPD patients{\textquoteright} health.Significant adverse associations were found between the respiratory health of COPD patients and their personal exposure to gaseous pollutants measured using portable sensors over 6 months. No significant associations were found for particulate pollutants. https://bit.ly/3aqMT6O}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/58/1/2003432}, eprint = {//www.qdcxjkg.com/content/58/1/2003432.full.pdf}, journal = {European Respiratory Journal} }