RT期刊文章SR电子T1 spirometr回家y in patients with idiopathic pulmonary fibrosis: data from the INMARK trial JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 2001518 DO 10.1183/13993003.01518-2020 VO 58 IS 1 A1 Noth, Imre A1 Cottin, Vincent A1 Chaudhuri, Nazia A1 Corte, Tamera J. A1 Johannson, Kerri A. A1 Wijsenbeek, Marlies A1 Jouneau, Stephane A1 Michael, Andreas A1 Quaresma, Manuel A1 Rohr, Klaus B. A1 Russell, Anne-Marie A1 Stowasser, Susanne A1 Maher, Toby M. YR 2021 UL //www.qdcxjkg.com/content/58/1/2001518.abstract AB Background Data from the INMARK trial were used to investigate the feasibility and validity of home spirometry as a measure of lung function decline in patients with idiopathic pulmonary fibrosis (IPF).Methods Subjects with IPF and preserved forced vital capacity (FVC) were randomised to receive nintedanib or placebo for 12 weeks followed by open-label nintedanib for 40 weeks. Clinic spirometry was conducted at baseline and weeks 4, 8, 12, 16, 20, 24, 36 and 52. Subjects were asked to perform home spirometry at least once a week and ideally daily. Correlations between home- and clinic-measured FVC and rates of change in FVC were assessed using Pearson correlation coefficients.Results In total, 346 subjects were treated. Mean adherence to weekly home spirometry decreased over time but remained above 75% in every 4-week period. Over 52 weeks, mean adherence was 86%. Variability in change from baseline in FVC was greater when measured by home rather than clinic spirometry. Strong correlations were observed between home- and clinic-measured FVC at all time-points (r=0.72–0.84), but correlations between home- and clinic-measured rates of change in FVC were weak (r=0.26 for rate of decline in FVC over 52 weeks).Conclusion Home spirometry was a feasible and valid measure of lung function in patients with IPF and preserved FVC, but estimates of the rate of FVC decline obtained using home spirometry were poorly correlated with those based on clinic spirometry.In a 52-week study in 346 subjects with idiopathic pulmonary fibrosis, mean adherence to weekly home spirometry was 86%. Estimates of the rate of decline in forced vital capacity obtained using home and clinic spirometry were poorly correlated. https://bit.ly/2WjIQ4b