PT - JOURNAL ARTICLE AU - frachiger, Bettina S. AU - Binggeli, Severin AU - Yammine, Sophie AU - Spycher, Ben AU - Krüger, Linn AU - Ramsey, Kathryn A. AU - Latzin，菲利普TI -纵向临床肺的间隙与囊性纤维化指数在儿童援助- 10.1183/13993003.02686 -2020 DP - 2021年7月01 TA -欧洲呼吸杂志》第六PG - 2002686 - 58 IP - 1 4099 - //www.qdcxjkg.com/content/58/1/2002686.short 4100 - //www.qdcxjkg.com/content/58/1/2002686.full所以和欧元J2021 7月01;虽然肺清除率(LCI)是囊性纤维化(CF)患者小气道疾病的敏感标志物，但在常规临床监测中，对LCI的纵向变化了解较少。在此，我们的目标是描述常规临床监测期间CF患儿LCI的纵向病程，并评估影响因素。方法2011 - 2018年，3 - 18岁CF患儿每3个月进行一次LCI测量，作为常规临床护理的一部分。我们记录每次就诊的临床数据。我们使用多水平混合效应模型来确定LCI随时间的变化，并确定影响LCI病程的临床因素。我们收集了来自78名参与者的1204次访问(3603次试验)的LCI测量数据，其中907次访问具有可接受的LCI数据。整个人群的平均未调整的LCI增长为0.29 (95% CI 0.20-0.38) LCI单位·一年−1。LCI的增加在青春期更为显著(0.41 (95% CI 0.27-0.54) LCI单位·年−1)。铜绿假单胞菌或烟曲霉定植、肺加重、cf相关糖尿病和支气管肺曲霉病与LCI随时间的增高相关。 Adjusting for clinical risk factors reduced the increase in LCI over time to 0.24 (95% CI 0.16–0.33) LCI units·year−1.Conclusions LCI measured during routine clinical surveillance is associated with underlying disease progression in children with CF. An increased change in LCI over time should prompt further diagnostic intervention.The lung clearance index (LCI) is sensitive to assess lung disease progression in children with CF in routine clinical care. An increased change in LCI should prompt further diagnostic intervention to determine the underlying pathological process. https://bit.ly/3ae9Rhp