@Article {Murray2003599，作者= {Murray，Clare S.和Lucas，Sarah J.和Blakey，John和Kaplan，Alan和Papi，Alberto和Paton，James和Phipatanakul，Wanda和Phipatanakul，Wanda和Price，David和Teoh，Oon Hoe和Thomas，麦克风和特纳，史蒂夫和帕帕多洛斯，尼古拉罗萨·}，标题= {现实生活比较有效性研究在初级保险中加入哮喘加剧的管理}，体积= {58}，数字= {1}，Elocation-id = {2003599}，年= {2021}，DOI = {10.1183 / 13993003.03599-2020}，出版商= {欧洲呼吸社会}，摘要= {188bet官网地址背景哮喘加剧是哮喘发病率和死亡率的主要贡献者。它们通常用支气管扩张剂和口腔皮质类固醇（OCS）进行管理，但临床试验证据表明抗生素可能是有益的。我们的旨在评估患有抗生素的哮喘加剧治疗较大，更具代表性的常规护理人群的改善的结果。方法使用最佳患者进行呼吸系统对比较有效性与OCS的哮喘加剧的研究。使用最佳患者进行抗生素。护理研究数据库。数据集包括28名637名患者;倾向倾向分数20 024成年人和4184名儿童进行了分析。除了OCS之外还在45 \％的成人和32岁儿童治疗哮喘恶化的情况下进行抗生素。与单独的OCS相比，OCS加抗生素在以下2周内减少哮喘/喘息咨询的风险降低（儿童危害比（HR）0.84（95℃）0.84（95×％CI 0.73 {\ Textendash} 0.96），P = 0.012;成人HR 0.86（95 \％CI 0.81 {\ Textendash} 0.91），p \ <0.001），但在成人6周内进一步的OCS处方的风险增加（HR 1.11（95 \％）CI 1.01 {\ TextEndash} 1.21），P = 0.030），但不是孩子。 Penicillins, but not macrolides, were associated with a reduction in the odds of a subsequent asthma/wheeze consultation compared to OCS alone, in both adults and children.Conclusion Antibiotics were frequently prescribed in relation to asthma exacerbations, contrary to guideline recommendations. Overall, the routine addition of antibiotics to OCS in the management of asthma exacerbations appeared to confer little clinical benefit, especially when considering the risks of antibiotic overuse.Antibiotics are regularly prescribed for asthma exacerbation; however, there is little clinical benefit to the routine addition of antibiotics to usual OCS treatment for managing asthma exacerbations in primary care patients https://bit.ly/2LvYbfT}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/58/1/2003599}, eprint = {//www.qdcxjkg.com/content/58/1/2003599.full.pdf}, journal = {European Respiratory Journal} }