@Article {Dutra Silva2002978，作者= {Dutra Silva，Johnatas和Su，Yue和Calfee，Carolyn S.和Delucchi，Kevin L.和Weiss，Weiss，Daniel和McAuley，Danny F.和O {，Anna D.}，title = {间充质基质细胞外囊泡挽救线粒体功能障碍并改善临床相关模型的ARDS}，volume = {58}，number = {1}，Elocation-ID = {2002978}，lumber = {58}= {2021}，doi = {10.1183/13993003.02978-2020}，Publisher = {欧洲188bet官网地址呼吸道社会}，摘要= {肺泡上皮{\ textEndEndash}毛细管壁垒破坏是急性呼吸窘迫综合症的标志。线粒体功能障碍对ARDS中受损的肺泡毛细管屏障的贡献尚不清楚。间充质基质细胞衍生的细胞外囊泡（MSC-EV）被认为是无细胞的ARDS治疗。线粒体转移对MSC和MSC-EV的治疗作用很重要。在这里，我们研究了线粒体功能障碍对ARDS肺泡上皮和内皮屏障的损伤的贡献，以及MSC-EVS调节肺泡{\ textEndEndash}毛细管壁垒的能力，通过线粒体通过线粒体转移。用ARDS患者的内毒素或血浆样品刺激了人类精确切割的肺切片（PCLS），并评估了MSC-EV，屏障特​​性和线粒体功能的治疗。用MSC-EVS和肺损伤程度处理脂多糖（LPS）染色的小鼠，并评估肺组织的线粒体呼吸。炎症刺激导致渗透性与两种类型的原代细胞和pclss中明显的线粒体功能障碍相连的渗透性增加。源自正常MSC的细胞外囊泡恢复了屏障完整性和正常水平的氧化磷酸化水平，而不含线粒体的细胞外囊泡制剂无效。 In vivo, presence of mitochondria was critical for extracellular vesicles ability to reduce lung injury and restore mitochondrial respiration in the lung tissue.In the ARDS environment, MSC-EVs improve alveolar{\textendash}capillary barrier properties through restoration of mitochondrial functions at least partially via mitochondrial transfer.This study demonstrates that mitochondrial dysfunction is an important mechanism of ARDS pathogenesis. Mitochondrial transfer is crucial for the ability of MSC extracellular vesicles to restore integrity of the alveolar{\textendash}capillary barrier. https://bit.ly/2JuqoCY}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/58/1/2002978}, eprint = {//www.qdcxjkg.com/content/58/1/2002978.full.pdf}, journal = {European Respiratory Journal} }