@Article {Schweitzer2003988，作者= {Schweitzer，Kelly S.和Crue，Taylor和Nall，Jordan M.和Foster，Jordan M.和Foster，Daniel和Sajuthi，Satria和Satria和Correll，Kelly A.以及Nakamura，Nakamura，Mari和Everman和Everman和Everman，Jamie L.和Jamie L.和Downey，Downey，Downey，downey，，Downey，，Downey，，，Downey，，，，唐尼Gregory P.和Seibold，Max A.和Bridges，James P.和Serban，Karina A.和Chu，Hong Wei和Petrache，Irina}，title = {流感病毒感染增加了ACE2的表达，并在人类的小型呼吸道上皮细胞中散发出来，音量= {58}，number = {1}，Elocation-id = {2003988}，年= {2021}，doi = {10.1183/13993003.03988-2020}188bet官网地址由严重急性呼吸综合征2（SARS-COV-2）引起的冠状病毒疾病2019（CoVID-19）表明，与呼吸道病毒的共感染率很高，包括流感（IAV），提示致病性相互作用。IAV可能会增加COVID-19-19-lung疾病的风险，重点关注受体血管紧张素转换酶（ACE）2和蛋白酶TMPRSS2在细胞内摄取SARS-COV-2中合作。我们发现，我们发现，使用远端人类非肺均质质量的单细胞RNA测序，在基线时，ACE2在基础上以最小的基础表达，在基础上表达了最小的表达，杯状，纤毛和分泌的上皮细胞填充了小气道。我们专注于人类小气道上皮细胞（SAEC），这是病毒感染后肺损伤发病机理的中心。来自非疾病的供体肺的初级SAEC，带有IAV（最多3 {\ texttimes} 105 Pfu; \〜{} 1多重感染（八倍），带有IAV（最多3 {\ texttimes} 105 pfu; \〜{}）显着增强了表达的表达ACE2，与STAT1平行的ACE2，这是一种由病毒激活的转录因子。IAV增加了细胞内ACE2的明显电泳迁移率，并在顶端分泌中产生了ACE2片段（90 kDa），表明该受体的裂解。 In addition, IAV increased the expression of two proteases known to cleave ACE2, sheddase ADAM17 (TACE) and TMPRSS2 and increased the TMPRSS2 zymogen and its mature fragments, implicating proteolytic autoactivation.Conclusion These results indicate that IAV amplifies the expression of molecules necessary for SARS-CoV-2 infection of the distal lung. Furthermore, post-translational changes in ACE2 by IAV may increase vulnerability to lung injury such as acute respiratory distress syndrome during viral co-infections. These findings support efforts in the prevention and treatment of influenza infections during the COVID-19 pandemic.Influenza virus infection of cells lining the small airways increases the expression of molecules required for SARS-CoV-2 uptake in a manner that predicts increased severity of lung disease in those co-infected with influenza and coronaviruses https://bit.ly/3nu1WAo}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/58/1/2003988}, eprint = {//www.qdcxjkg.com/content/58/1/2003988.full.pdf}, journal = {European Respiratory Journal} }