TY - JOUR T1 -严重哮喘问卷:灵敏度变化和最小临床重要差异JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00300 -2021欧元六世- 57 - 6 SP - 2100300 AU Masoli马修AU - Lanario,约瑟夫·w . AU -海兰德,迈克尔•e . AU - Menzies-Gow Andrew AU -曼苏尔,阿德尔h . AU -艾伦,大卫AU -多德,詹姆斯·w . AU -海斯吉玛AU - Valderas Jose m . AU -羊肉,莎拉·e . AU -琼斯,鲁珀特·c·Y1 - 2021/06/01 UR - //www.qdcxjkg.com/content/57/6/2100300.abstract N2 -严重哮喘问卷(SAQ)是一种有效的衡量健康相关的生活质量严重哮喘患者[1]。SAQ的最小临床重要差异(MCID)尚未计算。MCID用于表示临床意义而不是统计意义。MCID的计算方法主要有两种。分布方法根据分数的分布与平均变化分数之间的关系来定义MCID。这些方法是纯统计的，构成MCID的关系和公式是由惯例确定的。相比之下，定位点方法[2]根据独立定位点或标准定义MCID。当锚点是病人感知到的他们的状况的一个刚刚明显的差异时，锚点法比分布法有两个优势。 First, the MCID is defined by a criterion and, therefore, has criterion validity rather than being only a convention. Second, the MCID is defined in terms of the patient's perception of treatment, and the patient's perception of their treatment is recognised as being an important outcome for clinical decision-making [2]. In this letter we present the MCID of the SAQ using the anchor method.The Severe Asthma Questionnaire (SAQ) is sensitive to change and clinically significant improvement was detected within 4 weeks of starting biologic therapy. The MCID of the SAQ is 0.5 and of the SAQ-global is 11. https://bit.ly/3poJqcG ER -