TY -的T1 -加速肺功能下降史的成年人汇出儿童哮喘JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00305 -2021欧元SP - 2100305 AU Shinichiro三浦AU - Hiroshi Iwamoto盟Keitaro Omori AU - Kakuhiro山口盟Shinjiro坂本盟靖Horimasu AU - Masuda武盟Shintaro宫本茂盟佐藤中岛美嘉AU -其它安装盟Hironobu岩漠AU -天皇Yokoyama盟现任服部年宏Y1 - 2021/01/01 UR - //www.qdcxjkg.com/content/early/2021/06/10/13993003.00305 - 2021. -抽象N2 -目的大量儿童哮喘缓解期显示在成年。虽然这些成年人往往被诊断为慢性阻塞性肺疾病在以后的生活中,临床汇出儿童哮喘的影响肺功能的下降在成年期是不确定的。我们检查了儿童哮喘的临床缓解期是否与加速肺功能下降显然non-asthmatic成年人。方法在这里,3584名参与者(平均年龄48.1岁;范围内,35 - 65岁)没有成年哮喘和其他肺部疾病和肺功能正常基线包括访问。他们被归类为:那些汇出儿童哮喘(n = 121)和健康对照组(n = 3463)根据他们的自我报告的儿童哮喘历史。肺量测定法进行了基线,后续访问。结果平均随访时间5.3年。多元回归分析表明,汇出儿童哮喘和吸烟是独立与快速用力呼气量下降1 s (FEV1)、用力肺活量(FVC)。此外,吸烟是一个独立的预测FEV1 / FVC的快速下降。年度FEV1下降和FVC也显著大于在参与者汇出比健康对照组儿童哮喘,和调整后,差异仍然显著倾向得分。结论临床汇出儿童哮喘的历史是一个独立的危险因素加速肺功能下降的成年人。汇出儿童哮喘,吸烟可能分析加速阻塞性肺疾病的发展。FootnotesThis手稿最近发表在《欧洲呼吸杂志》上。 It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Miura has nothing to disclose.Conflict of interest: Dr. Iwamoto has nothing to disclose.Conflict of interest: Dr. Omori has nothing to disclose.Conflict of interest: Dr. Yamaguchi has nothing to disclose.Conflict of interest: Dr. Sakamoto has nothing to disclose.Conflict of interest: Dr. Horimasu has nothing to disclose.Conflict of interest: Dr. Masuda has nothing to disclose.Conflict of interest: Dr. Miyamoto has nothing to disclose.Conflict of interest: Dr. Nakashima has nothing to disclose.Conflict of interest: Dr. Fujitaka has nothing to disclose.Conflict of interest: Dr. Hamada has nothing to disclose.Conflict of interest: Dr. Yokoyama has nothing to disclose.Conflict of interest: Dr. Hattori reports grants from Teijin Pharma Co., Japan, during the conduct of the study;. ER -