PT -期刊文章盟Pham泰盟——Pesenti安东尼奥盟——Bellani Giacomo AU -·鲁本菲尔德,戈登AU -风扇,艾迪盟——Bugedo Guillermo盟——Lorente何塞天使AU -费尔南德斯,Antero淡水河谷盟——范·哈伦的弗兰克AU - Bruhn,亚历杭德罗盟——里奥斯,费尔南多- AU -埃斯特万,安德烈斯盟——Gattinoni卢西亚诺AU -拉尔森,安德斯AU - McAuley,丹尼尔·f . AU -拉涅利,马可AU -汤普森,b .泰勒盟——Wrigge赫尔曼盟——Brochard Laurent j . AU - Laffey约翰·g·埃德-,TI -急性低氧性呼吸衰竭的结局:来自LUNG SAFE Study AID - 10.1183/13993003.03317-2020 DP - 2021年6月01日TA -欧洲呼吸杂志PG - 2003317 VI - 57 IP - 6 4099 - //www.qdcxjkg.com/content/57/6/2003317.short 4100 - //www.qdcxjkg.com/content/57/6/2003317.full SO - Eur Respir J2021年6月01日;目前重症监护室(ICU)中需要机械通气的急性低氧性呼吸衰竭患者的发病率和结局尚不清楚，特别是对于不符合急性呼吸窘迫综合征(ARDS)标准的患者。2014年冬季，来自50个国家的459个icu连续4周对机械通气早期出现低氧血症的患者进行了国际、多中心、前瞻性队列研究(LUNG SAFE)。动脉氧张力/吸气氧分数比值≤300mmhg，有新的肺浸润，需要机械通气，呼气末正压≥5cmh2o。测量ICU患病率、低氧血症原因、住院生存率和与医院死亡率相关的因素。对单侧和双侧混浊患者进行比较。结果12 906例危重患者接受机械通气，34.9%的患者出现低氧血症和新的浸润，分为ARDS(69.0%)、单侧浸润(22.7%)和充血性心力衰竭(CHF;8.2%)。全球医院死亡率为38.6%。CHF患者的死亡率与ARDS相当(44.1%对40.4%)。 Patients with unilateral-infiltrate had lower unadjusted mortality, but similar adjusted mortality compared to those with ARDS. The number of quadrants on chest imaging was associated with an increased risk of death. There was no difference in mortality comparing patients with unilateral-infiltrate and ARDS with only two quadrants involved.Interpretation More than one-third of patients receiving mechanical ventilation have hypoxaemia and new infiltrates with a hospital mortality of 38.6%. Survival is dependent on the degree of pulmonary involvement whether or not ARDS criteria are reached.Patients with hypoxaemic respiratory failure represent more than one-third of patients requiring mechanical ventilation and their mortality often exceeds 40%. Adjusting for severity, mortality is similar whether it is unilateral or bilateral (as in ARDS). https://bit.ly/2VshdWc