％0刊期刊文章％A Crichton，Megan L.％乳糖，艾米丽K.％A Shoemark，Amelia％的Chalmers，James D.％T验证支气管扩张措施（BIM）：一种新的患者报告的结果测量％D 2021％R 10.1183 / 13993003.03156-2020％J欧洲呼吸轴颈％p 2003156％v 57％n 5％x简介支气管扩张试验中使用的现有生活质量和症状工具是不是疾病特异性或复杂的并且没有一直响应。我们开发了一种简单的患者报告的视觉模拟结果测量，支气管扩张措施（BIM），用于临床研究，包括临床试验。邀请在苏格兰东部参加苏格兰东部推荐诊所的支气管扩张患者完成BIM在2周和6个月后，基线调查问卷和生活质量支气管扩张问卷调查问卷。我们通过评估在急性加剧期间的变化来评估内部一致性，测试 - 重度可靠性，构建有效性和响应性。结果173名患者。八个域（咳嗽，痰，呼吸困难，疲倦，活动，一般健康，控制，加剧）表现出优异的内部一致性（Cronbach的α0.93）。脑内相关系数在2周内显示出优异的可靠性：咳嗽（0.79,95％CI 0.85），痰（0.86,95％CI 0.80-0.90），呼吸困难（0.82,95％CI 0.74-0.87），疲倦（0.88,95％CI 0.82-0.91），活动（0.84,95％CI 0.77-0.89），一般健康（0.81,95％CI 0.74-0.87），对照（0.83,95％CI 0.75-0.88）和加剧（0.71,95％CI 0.60-0.79）。 Domains correlated strongly with bronchiectasis severity and exacerbation history. Both distribution and patient-based methods estimated the minimal clinically important difference for each domain as 1.5 points on a 10-point scale. Statistically significant changes in all BIM domains were observed during an acute exacerbation.Conclusion The BIM is a simple patient-reported outcome. This study validates the internal consistency, reliability, construct validity and response of the tool at acute exacerbation. Further validation of the tool is now required.This study validates a novel patient-reported outcome for patients with bronchiectasis. The Bronchiectasis Impact Measure (BIM) is repeatable, content valid and responsive to change, and may be a useful outcome measure for testing new therapies. https://bit.ly/3pean44 %U //www.qdcxjkg.com/content/erj/57/5/2003156.full.pdf