RT期刊文章SR电子T1缩短静脉抗生素治疗的可行性基于细菌负荷——一个概念证明随机对照试验摩根富林明欧洲呼吸杂志乔和J FD欧元欧洲呼吸学会SP 2004388 10.1183/13993003.04388 -2020 A1·贝迪Pallavi A1 Cartlidge, Manjit k A1张,188bet官网地址杨A1 Turnbull, Kim A1 Donaldson, Samantha A1 Clarke, Andrea A1 Crowe, Jane A1 Campbell, Kadiga A1 Graham, Catriona A1 Franguylan, Ruzanna A1 Rossi, Adriano G. A1 Hill，Adam T. YR 2021 UL //www.qdcxjkg.com/content/early/2021/05/20/13993003.04388-2020.abstract AB介绍缺乏证据指导支气管扩张加重的静脉注射抗生素的持续时间。目的评估基于细菌负荷来缩短急性加重期静脉使用抗生素是否可行，以及14天治疗是否优越。方法:招募需要静脉注射抗生素治疗急性加重的患者。参与者随机分为两组，接受抗生素治疗14天或细菌负荷引导组(BLGG)。在0/7/10/14/21天检查细菌载量。如果BLGG在第7天和第10天的细菌负荷<106 cfu·mL−1，则在第2天停用抗生素。结果14 d抗生素47例，BLGG 43例。BLGG组88%的参与者在第8天停用了抗生素，而在14天组中，可能有81%的参与者在第8天停用了抗生素。与BLGG相比，第21天和第14天的临床改善无显著增加趋势。然而，总体组数据显示，接受抗生素治疗14天的组到下一次发作的中位(四分位数范围)时间为27.5天(12.5-60天)，BLGG组为60天(18-110天);p = 0.0034。 In Cox proportional hazard model, 14 days was more likely to experience exacerbations (Hazard Ratio(95% CI)1.80 (1.16–2.80), p=0.009 compared to BLGG and those with mild bronchiectasis less likely to experience exacerbations than patients with more severe bronchiectasis (HR 0.359 (0.13–0.99), p=0.048).Conclusion Bacterial load guided therapy is feasible in most exacerbations requiring intravenous antibiotics. There was a non-significant trend for increased clinical improvement by day21 with 14 day antibiotics compared with BLGG but paradoxically there was a prolonged time to next exacerbation in BLGG.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Bedi has nothing to disclose.Conflict of interest: Dr. Cartlidge has nothing to disclose.Conflict of interest: Dr. Zhang has nothing to disclose.Conflict of interest: Dr. Turnbull has nothing to disclose.Conflict of interest: Dr. Donaldson has nothing to disclose.Conflict of interest: Dr. Clarke has nothing to disclose.Conflict of interest: Mrs Crowe has nothing to disclose.Conflict of interest: Mrs Campbell has nothing to disclose.Conflict of interest: Dr. Graham reports grants from scottish office, during the conduct of the study; .Conflict of interest: Dr. Frangulyan has nothing to disclose.Conflict of interest: Prof. Rossi has nothing to disclose.Conflict of interest: Prof. Hill has nothing to disclose.