@Article {Bedi2004388,作者= {Bedi,Pallavi和Cartlidge,Manjit K.和Zhang,Yang和Transbull,Kim和Donaldson,Samantha和Clarke,Andrea和Crowe,Jane和Campbell,Kadiga和Graham,Catriona和Franguylan,Ruzanna和Franguylan,Ruzanna和FranguylanRossi,Adriano G.和Hill,Adam T.},标题= {缩短静脉抗生素治疗的可行性,基于细菌负载 - 概念随机控制试验的证据},Elocation-Id = {2004388},年= {2021},DOI = {10.1183 / 13993003.04388-2020},出版商= {欧洲呼吸社会188bet官网地址},摘要= {介绍缺乏指导静脉内抗生素的持续时间用于支气管扩张的证据。为了评估是否可行的基于细菌载荷来缩短加剧期间的静脉抗生素以及14天治疗是否优于。我们招募了需要静脉抗生素的参与者进行加剧。参与者被随机分为两组以接受14天或细菌负荷引导组(BLGG)的抗生素。在第0/7/10/14/21天检查细菌载荷。如果BLGG中的细菌载荷是\ <106 CFU {\ TextHiodcentered} ML-1,则在第二天停止抗生素。抗生素47在Blgg中获得14天抗生素和43。88 \%BLGG的参与者能够在第8天停止抗生素,并且可能在14天的第8天内停止抗生素。与BLGG相比,第21天通过第21天提高了临床改善的非显着趋势。然而,总体组数据显示中位数(胎面范围)时间达到下一次加剧时间为27.5(12.5 {\ TextEndash} 60)在Blgg中接受抗生素的组,在Blgg中的60天(18 {\ TextEndash} 110)天; p=0.0034. In Cox proportional hazard model, 14 days was more likely to experience exacerbations (Hazard Ratio(95\% CI)1.80 (1.16{\textendash}2.80), p=0.009 compared to BLGG and those with mild bronchiectasis less likely to experience exacerbations than patients with more severe bronchiectasis (HR 0.359 (0.13{\textendash}0.99), p=0.048).Conclusion Bacterial load guided therapy is feasible in most exacerbations requiring intravenous antibiotics. There was a non-significant trend for increased clinical improvement by day21 with 14 day antibiotics compared with BLGG but paradoxically there was a prolonged time to next exacerbation in BLGG.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Bedi has nothing to disclose.Conflict of interest: Dr. Cartlidge has nothing to disclose.Conflict of interest: Dr. Zhang has nothing to disclose.Conflict of interest: Dr. Turnbull has nothing to disclose.Conflict of interest: Dr. Donaldson has nothing to disclose.Conflict of interest: Dr. Clarke has nothing to disclose.Conflict of interest: Mrs Crowe has nothing to disclose.Conflict of interest: Mrs Campbell has nothing to disclose.Conflict of interest: Dr. Graham reports grants from scottish office, during the conduct of the study; .Conflict of interest: Dr. Frangulyan has nothing to disclose.Conflict of interest: Prof. Rossi has nothing to disclose.Conflict of interest: Prof. Hill has nothing to disclose.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/early/2021/05/20/13993003.04388-2020}, eprint = {//www.qdcxjkg.com/content/early/2021/05/20/13993003.04388-2020.full.pdf}, journal = {European Respiratory Journal} }