TY - T1的协会在学龄前儿童哮喘控制轨迹之间和疾病缓解JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01897 -2020欧元六世- 57 - 5 SP - 2001897 AU -隆戈,克里斯蒂娜AU - Blais,露西AU -布劳内尔,Marni AU -鹌鹑,杰奎琳·m . AU - Sadatsafavi Mohsen盟——忘记,天使爱美丽盟——Turcot Marc-Andre AU -聂,姚明AU -李,Wenbin AU - Tavakoli哈米德AU - Tan Qier AU -风扇,宇新AU -普拉特,Robert w . AU - Ducharme,弗朗辛·m·Y1 - 2021/05/01 UR - //www.qdcxjkg.com/content/57/5/2001897.abstract N2 -介绍早期疾病发病率与哮喘有关的持久性喘息学龄前儿童;然而,哮喘控制轨迹后不久,诊断是否会影响缓解是未知的。我们检查了哮喘控制轨迹之间的关系2年post-diagnosis学龄前儿童和随后的疾病缓解。方法:我们进行了一项多中心回顾性队列研究组成的5岁前48 687儿童患有哮喘诊断和1990年至2013年间出生的加拿大四省post-diagnosis曾长期疾病活动。长期的疾病活动被定义为一个或多个医疗访问或治疗哮喘的每6个月期限至少四post-diagnosis的六个时期。3年随访开始post-diagnosis(队列条目)。缓解被定义为连续2年没有药物或医疗访问队列条目后哮喘或会条件。哮喘控制轨迹,确定在四6个月期诊断使用验证索引后,被归类为:“在控制”,“改善控制”,“控制恶化”,“失控在”和“波动控制”。调整Cox模型估计缓解哮喘控制轨迹和时间之间的联系。一个随机效应分析总结province-specific风险比率(小时)。Results The pooled remission rate was 8.91 (95% CI 8.80–9.02) per 100 person-years. Compared with children controlled throughout, poorer asthma control was associated with incrementally lower hazard ratios of remission in four other trajectories: improving control (HR 0.89, 95% CI 0.82–0.96), fluctuating control (HR 0.78, 95% CI 0.71–0.85), worsening control (HR 0.68, 95% CI 0.62–0.75) and out of control throughout (HR 0.52, 95% CI 0.45–0.59).Conclusions Asthma control trajectories 2 years following a diagnosis in preschoolers were associated with remission, highlighting the clinical relevance of documenting control trajectories in early life.In this multicentre population-based cohort study, the worse the asthma control trajectory shortly following diagnosis in preschoolers, the lower the likelihood of remission https://bit.ly/3lHVsNf ER -