A Longo, Cristina %A Blais, Lucie %A Brownell, Marni %A鹌鹑，Jacqueline M. %A Sadatsafavi, Mohsen %A Forget, Amélie %A Turcot, Marc-André %A Nie, Yao %A Li, Wenbin %A Tavakoli, Hamid %A Tan, Qier %A Fan, Yuxin %A Platt, Robert W. A Ducharme，作者:Francine M. %T Association between asthma control pathways in学龄前儿童哮喘控制轨迹与疾病缓解之间的相关性然而，诊断后不久的哮喘控制轨迹是否会影响缓解尚不清楚。我们研究了学龄前儿童诊断后2年哮喘控制轨迹与随后疾病缓解之间的关系。方法:我们进行了一项多中心基于人群的回顾性队列研究，包括48 687名5岁前确诊和1990年至2013年出生的加拿大4个省份的哮喘儿童，他们在诊断后疾病活动延长。延长的疾病活动被定义为每6个月至少有4个月的哮喘就诊或药物治疗。随访开始于诊断后3年(队列进入时)。缓解定义为在队列入组后连续2年无哮喘或哮喘样疾病药物索赔或就诊。哮喘控制轨迹在诊断后的4个6个月期间内确定，使用有效的指标，分为:“完全控制”、“改善控制”、“恶化控制”、“完全失控”和“波动控制”。经调整的Cox模型估计了哮喘控制轨迹和缓解时间之间的关联。 A random effects meta-analysis summarised province-specific hazard ratios (HRs).Results The pooled remission rate was 8.91 (95% CI 8.80–9.02) per 100 person-years. Compared with children controlled throughout, poorer asthma control was associated with incrementally lower hazard ratios of remission in four other trajectories: improving control (HR 0.89, 95% CI 0.82–0.96), fluctuating control (HR 0.78, 95% CI 0.71–0.85), worsening control (HR 0.68, 95% CI 0.62–0.75) and out of control throughout (HR 0.52, 95% CI 0.45–0.59).Conclusions Asthma control trajectories 2 years following a diagnosis in preschoolers were associated with remission, highlighting the clinical relevance of documenting control trajectories in early life.In this multicentre population-based cohort study, the worse the asthma control trajectory shortly following diagnosis in preschoolers, the lower the likelihood of remission https://bit.ly/3lHVsNf %U //www.qdcxjkg.com/content/erj/57/5/2001897.full.pdf