TY - T1的协会在学龄前儿童哮喘控制轨迹之间和疾病缓解JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01897 -2020欧元六世- 57 - 5 SP - 2001897 AU -隆戈,克里斯蒂娜AU - Blais,露西AU -布劳内尔,Marni AU -鹌鹑,杰奎琳·m . AU - Sadatsafavi Mohsen盟,忘记,Amélie AU - Turcot, Marc-André AU - Nie, Yao AU - Li, Wenbin AU - Tavakoli, Hamid AU - Tan, Qier AU - Fan, Yuxin AU - Platt, Robert W. AU - Ducharme，早期疾病发病率与学龄前喘息儿童哮喘持续存在相关;然而，诊断后不久的哮喘控制轨迹是否会影响缓解尚不清楚。我们研究了学龄前儿童诊断后2年哮喘控制轨迹与随后疾病缓解之间的关系。方法:我们进行了一项多中心基于人群的回顾性队列研究，包括48 687名5岁前确诊和1990年至2013年出生的加拿大4个省份的哮喘儿童，他们在诊断后疾病活动延长。延长的疾病活动被定义为每6个月至少有4个月的哮喘就诊或药物治疗。随访开始于诊断后3年(队列进入时)。缓解定义为在队列入组后连续2年无哮喘或哮喘样疾病药物索赔或就诊。哮喘控制轨迹在诊断后的4个6个月期间内确定，使用有效的指标，分为:“完全控制”、“改善控制”、“恶化控制”、“完全失控”和“波动控制”。 Adjusted Cox models estimated associations between asthma control trajectories and time to remission. A random effects meta-analysis summarised province-specific hazard ratios (HRs).Results The pooled remission rate was 8.91 (95% CI 8.80–9.02) per 100 person-years. Compared with children controlled throughout, poorer asthma control was associated with incrementally lower hazard ratios of remission in four other trajectories: improving control (HR 0.89, 95% CI 0.82–0.96), fluctuating control (HR 0.78, 95% CI 0.71–0.85), worsening control (HR 0.68, 95% CI 0.62–0.75) and out of control throughout (HR 0.52, 95% CI 0.45–0.59).Conclusions Asthma control trajectories 2 years following a diagnosis in preschoolers were associated with remission, highlighting the clinical relevance of documenting control trajectories in early life.In this multicentre population-based cohort study, the worse the asthma control trajectory shortly following diagnosis in preschoolers, the lower the likelihood of remission https://bit.ly/3lHVsNf ER -