TY-JUR T1 - 结核病患者联系人的接触调查有效性：系统审查和META分析JF - 欧洲呼吸期刊JO - EUR RESPIR J DO - 10.1183/13993003 - 2100266 Au - Velen，Kavindhran Au -Shingde，Rashmi Vijay Au - Ho，Jennifer Au - Fox，Greg James Y1 - 2021/01/01 UR - //www.qdcxjkg.com/content/early/2021/05/06/13993003.00266-2021.Abstract n2- 背景我们旨在评估与无源案例检测相比，单独的被动案例检测的效果，并估计了TB的患者联系人的共普遍和事故结核（TB）的产量和潜在结核病感染（LTBI）系统搜索是在2011年1月1日至2019年10月1日之间发表的学习的研究。估计诊断为共普遍的TB，入射TB和/或LTBI的触点的比例。评价接触调查的有效性包括随机试验，而在非随机性研究中评估接触调查（共普遍和事件TB和LTB）的产率。从244项研究中提取了数据，其中187项研究测量了比例诊断为TB疾病的触点和135项研究测量了LTBI流行。单独的随机试验表明，接触调查增加了Tb案例通知（RR 2.5 [95％CI：2.0-3.2]），TB案例检测（或1.34 [95％CI：0.43-4.24]）和死亡率下降（RR 0.6 [95％]CI：0.4-0.8]）和群体TB患病率（风险比0.82 [95％CI：0.64-1.04]）。TB的总体汇总率为3.6％（95％CI：3.3-4.0％; I2 = 98.9％，181次研究）。 The pooled prevalence of microbiologically-confirmed TB was 3.2% (95% CI: 2.6–3.7%; I2=99.5%, 106 studies). The pooled incidence of TB was highest in the first year after exposure to index patients (2.0%, 95% CI: 1.1–3.3%; I2=96.2%, 14 studies) and substantially lower five years after exposure to index patient (0.5%, 95% CI: 0.3–0.9%; 1 study). The pooled prevalence of LTBI among contacts was 42.4% (95% CI: 38.5–46.4%; I2=99.8%, 135 studies).Conclusions and Relevance This systematic review and meta-analysis found that contact investigation was effective in high-burden settings. The higher pooled prevalence estimates of microbiologically-confirmed TB compared to previous reviews suggests newer rapid molecular diagnostics contribute to increased case detection.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Velen has nothing to disclose.Conflict of interest: Dr. Shingde has nothing to disclose.Conflict of interest: Dr. Ho has nothing to disclose.Conflict of interest: Dr. Fox has nothing to disclose. ER -