Ty-jour t1 - 血吸虫病相关肺动脉高压血管动力学的动脉血管体积变化JF - 欧洲呼吸杂志Jo - Eur Respir J Do - 10.1183 / 13993003.03914-2020 VL - 57是 - 5 SP - 2003914 Au - Rahaghi，Farbod n. AU - Hilton, Joan F. AU - Corrêa, Ricardo A. AU - Loureiro, Camila AU - Ota-Arakaki, Jaquelina S. AU - Verrastro, Carlos G.Y. AU - Lee, Michael H. AU - Mickael, Claudia AU - Nardelli, Pietro AU - Systrom, David A. AU - Waxman, Aaron B. AU - Washko, George R. AU - San José Estépar, Raúl AU - Graham, Brian B. AU - Oliveira, Rudolf K.F. Y1 - 2021/05/01 UR - //www.qdcxjkg.com/content/57/5/2003914.abstract N2 - Schistosomiasis is a prevalent cause of pulmonary arterial hypertension (PAH), currently classified as group 1 pulmonary hypertension (PH) [1]. In comparison to other aetiologies of PAH, such as idiopathic PAH, schistosomiasis-associated PAH (Sch-PAH) has not been extensively studied. Potential mechanisms of PAH development in schistosomiasis include systemic and localised lung inflammation, involvement of other organs, such as the liver and spleen, and direct blockage of precapillary vessels from parasite egg embolisation. Currently, the diagnosis of Sch-PAH relies on haemodynamic assessment using right heart catheterisation. In several aetiologies of PH, loss of visualised distal vascular volume has been quantified from pulmonary angiography [2, 3] and computed tomography (CT) of the lungs [4–6]. Additionally, loss of distal vascular volume has been shown to be associated with loss of vascular cross-sectional area histologically [7]. In this pilot study, we hypothesised that relative loss of arterial pulmonary vascular volume differentially correlates with haemodynamics in Sch-PAH patients, compared to a group of control subjects.Relative loss of vascular volume in small vessels compared to total vascular volume is a marker of pulmonary arterial hypertension in schistosomiasis and is correlated with pulmonary vascular remodelling by haemodynamics https://bit.ly/3bfIlAQ ER -