TY - T1的打捞急性内皮respiratory distress syndrome: a druggable intersection between TLR4 and NAD⁺ signalling JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.04588-2020 VL - 57 IS - 5 SP - 2004588 AU - Lee, Ji Young AU - Stevens, Reece P. AU - Migaud, Marie AU - Stevens, Troy Y1 - 2021/05/01 UR - //www.qdcxjkg.com/content/57/5/2004588.abstract N2 - The acute respiratory distress syndrome (ARDS) remains an intractable problem for intensivists, even with advancements in critical care and mechanical ventilation. Mortality rates in ARDS patients are around 35–45% [1]. However, these mortality numbers represent a conservative estimate of the ARDS healthcare impact, because survivors exhibit staggering rates of morbidity and mortality in the aftermath of their intensive care unit (ICU) stay, including neurocognitive dysfunction that can prohibit the return to activities of daily living [2, 3]. Development of medical therapies that improve both the short- and long-term outcomes of these critically ill patients remain an urgent unmet need.eNAMPT neutralisation may be effective treatment in acute respiratory distress syndrome https://bit.ly/3oaES9cWe thank Raymond Langley for his helpful discussions regarding the circulating metabolome in sepsis. ER -