TY - T1的腹泻在系统性硬化症帕特ients as a nocebo effect of nintedanib JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.03021-2020 VL - 57 IS - 4 SP - 2003021 AU - Bournia, Vasiliki-Kalliopi AU - Distler, Oliver AU - Kravvariti, Evrydiki AU - Mitsikostas, Dimos AU - Sfikakis, Petros P. Y1 - 2021/04/01 UR - //www.qdcxjkg.com/content/57/4/2003021.abstract N2 - Nocebo effects, the opposite of placebo effects, are defined as unfavourable changes in a patient's symptoms or condition occurring due to negative anticipation and possibly leading to suboptimal outcomes via treatment discontinuation or non-adherence [1]. Symptoms most commonly associated with nocebo in both dedicated neurobiological research and randomised controlled trial (RCT) settings are non-specific complaints, such as pain, malaise, dizziness or gastrointestinal upset [2]. Despite evidence highlighting the implications of placebo and nocebo effects on daily practice and RCT design and interpretation, determining their true frequency and intensity remains a challenge [1, 2].Nocebo effects may partly account for the high rates of diarrhoea reported in scleroderma patients enrolled in nintedanib RCTs. Investing in the doctor–patient relationship and improved informed consent procedures can reduce nocebo phenomena in trials. https://bit.ly/2VyoVhi ER -