TY - MRI的T1 -自由呼吸监测ventilation changes following antibiotic treatment of pulmonary exacerbations in paediatric cystic fibrosis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.03104-2020 VL - 57 IS - 4 SP - 2003104 AU - Munidasa, Samal AU - Couch, Marcus J. AU - Rayment, Jonathan H. AU - Voskrebenzev, Andreas AU - Seethamraju, Ravi AU - Vogel-Claussen, Jens AU - Ratjen, Felix AU - Santyr, Giles Y1 - 2021/04/01 UR - //www.qdcxjkg.com/content/57/4/2003104.abstract N2 - Treatment response in cystic fibrosis (CF) is traditionally monitored using pulmonary function tests (PFTs), such as spirometry. However, PFTs can be insensitive to treatment, particularly in early CF lung disease [1]. Hyperpolarised xenon-129 magnetic resonance imaging (Xe-MRI) has been shown to be feasible in children [2], more sensitive to early CF lung disease compared to PFTs [3] and captures improvements in ventilation inhomogeneity in paediatric CF patients receiving intravenous antibiotic treatment for a pulmonary exacerbation [4]. However, access to hyperpolarised 129Xe gas is not widely available, and Xe-MRI requires subjects to perform an extended breath-hold (10–15 s), which is challenging for very sick children.Ventilation distributions obtained with PREFUL MRI correlated with Xe-MRI, and both could detect improvements following treatment of a PEx. PREFUL MRI offers an effective and more widely available alternative to Xe-MRI for monitoring treatment. https://bit.ly/3le0TT9The authors would like to thank: Shahideh Safavi, Yonni Friedlander, Robert Grimm, Raymond Hu, Nikhil Kanhere, Krzysztof Kowalik, Andras Lindenmaier, Tammy Rayner, Laura Seed, Elaine Stirrat, Ruth Weiss, David Wilson, and Brandon Zanette for their assistance with data acquisition and analysis. ER -