RT期刊文章SR电子T1阻塞性睡眠呼吸暂停和间歇性缺氧的影响对血液流变学——转化研究摩根富林明欧洲呼吸杂志乔和J FD欧元欧洲呼吸学会SP 2100352 10.1183/13993003.00352 -2021 A1华尔兹,泽维尔A1 Beaudin,安德鲁·e·A1 Belaidi爱丽丝A1 Raneri,吉尔A1 Pepin,188bet官网地址jean - louis A1 Pialoux,文森特A1汉,Patrick j . A1路边,塞缪尔A1 Poulin,马克·j·年2021 UL //www.qdcxjkg.com/content/early/2021/04/08/13993003.00352 - 2021. -抽象AB理由行改变发表在阻塞性睡眠呼吸暂停(OSA)和扭转持续气道正压(CPAP),观察结果可能由间歇性缺氧(IH)诱导的氧化应激解释。目的探讨IH是否通过氧化应激引起血液流变学改变。方法Wistar大鼠7只，IH 8只，持续14 d。23例中度至重度OSA患者在3个时间点进行评估:基线、随机分为2周夜间供氧(n=13)或不进行治疗(n=10)和1个月的CPAP治疗(n=17)。此外，在基线和时间匹配的随访后评估无osa对照组(n=13)。我们测量了血液流变学参数[红细胞压积，血液粘度，血浆粘度(仅大鼠)，红细胞聚集和变形能力(仅人类)]和氧化还原平衡(SOD, GPX，蛋白质氧化[AOPP]和脂质过氧化[MDA])。我们还使用氧化剂t-丁基过氧化氢(TBHP)测试了人类参与者的红细胞对活性氧(ROS)的血液流变学敏感性。结果IH通过增加红细胞压积而提高大鼠血液粘度，但不改变红细胞的血液流变学特性。IH还降低了SOD活性，增加了AOPP。在人类中，患者和对照组之间的基线血液流变学特性相似，除了红细胞变形性在氧治疗后降低外，这些特性在氧和CPAP治疗后没有改变。 Redox balance was comparable between patients and controls. At baseline, TBHP induced a greater reduction of erythrocyte deformability in patients while CPAP reduced TBHP-induced increase in aggregation strength.Conclusion IH and OSA per se do not cause hemorheological alterations despite the presence of oxidative stress or higher sensitivity to ROS, respectively.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Waltz has nothing to disclose.Conflict of interest: Dr. Beaudin reports other from Canadian Institutes of Health Research - Heart and Stroke Foundation of Canada (HSFC), other from Alberta Innovates-Health Solutions (AIHS), from University of Calgary, during the conduct of the study.Conflict of interest: Dr. Beladi has nothing to disclose.Conflict of interest: Dr. Raneri has nothing to disclose.Conflict of interest: Dr. Pépin reports grants and other from Air Liquide Foundation, grants, personal fees and other from Agiradom, grants, personal fees and other from AstraZeneca, grants and personal fees from Fisher and Paykel, grants and personal fees from Mutualia, grants, personal fees and other from Philips, grants, personal fees and other from Resmed, grants and personal fees from Vitalaire, personal fees from Boehringer Ingelheim, personal fees from Jazz Pharmaceutical, personal fees from Night Balance, personal fees from Sefam, outside the submitted work.Conflict of interest: Dr. Pialoux has nothing to disclose.Conflict of interest: Dr. Hanly has nothing to disclose.Conflict of interest: Dr. Verges has nothing to disclose.Conflict of interest: Dr. Poulin has nothing to disclose.