TY -的T1 -持续正压通气改善血压和血清心血管生物标记物在阻塞性睡眠呼吸暂停和高血压JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.03687 -2020欧元SP - 2003687 AU -他,梅西Mei-Sze盟,谢霆锋Hung-Fat AU - Lam大卫Chi-Leung盟——刘治疗阻塞性睡眠呼吸暂停(OSA)对降低心血管风险的影响尚不清楚。本研究旨在探讨持续气道正压通气(CPAP)对阻塞性睡眠呼吸暂停和高血压患者的动态血压(BP)和亚临床心肌损伤的影响。方法选择需要至少3种降压药物治疗的高血压患者和中度-重度OSA患者。符合条件的受试者随机(1:1)接受CPAP治疗或对照组(无CPAP) 8周。比较动态血压和血清生物标志物的变化。按昼夜血压模式进行分层分析。主要结果92名受试者(75%为男性;年龄,51±8年;随机抽取呼吸暂停-低呼吸指数(40±8事件·h - 1)，平均服用3.4种降压药物[范围3-6]。CPAP治疗,与对照组相比,表现出显著减少24小时收缩压(−4.4毫米汞柱,95% CI 8.7−−0.1,p = 0.046), 24小时舒张压(−2.9毫米汞柱,95% CI 5.5−−0.2,p = 0.032),白天收缩压(−5.4毫米汞柱,9.7−−1.0,p = 0.016),白天舒张压(−3.4毫米汞柱,95% CI 6.1−−0.8,p = 0.012)。CPAP治疗与血压显著降低相关的只有非舀水者，而舀水者没有。 Serum troponin I (mean difference −1.74 pg·mL−1, 95% CI −2.97 to −0.5, p=0.006) and brain natriuretic peptide (−9.1 pg·mL−1, 95% CI −17.6 to −0.6, p=0.036) were significantly reduced in CPAP compared to control group.Conclusion In a cohort with OSA and multiple cardiovascular risk factors including difficult-to-control hypertension, short-term CPAP treatment improved ambulatory BP and alleviated subclinical myocardial injury and strain.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Lui has nothing to disclose.Conflict of interest: Dr. Tse has nothing to disclose.Conflict of interest: Dr. LAM has nothing to disclose.Conflict of interest: Dr. Lau reports grants, personal fees and non-financial support from Boerhinger Ingelheim, grants and non-financial support from Pfizer, grants from Sanofi, grants from Amgen, non-financial support from Eisai, outside the submitted work.Conflict of interest: Dr. Chan has nothing to disclose.Conflict of interest: M. Ip has nothing to disclose. ER -