作者@article {Bousema2001549 = {Bousema, Jelle e,艾亚茨Mieke j .和戴格拉,Marcel G.W. Annema, Jouke t和van den Broek,弗兰克J.C.}, title ={纵隔淋巴结分期的趋势及其对不可预见的N2和生存的影响在肺癌},体积= {57}= {4},elocation-id = {2001549} = {2021},近年来,可切除的非小细胞肺癌(NSCLC)有创纵隔淋巴结分期指南已经发生了变化。188bet官网地址本研究的目的是描述侵袭性分期和未预见N2 (uN2)的趋势,并评估其对总生存率的潜在影响。一项荷兰全国性队列研究包括了2005年至2017年期间所有经手术切除为主的IA IIIB期NSCLC患者(n=22 555)。我们评估了有创淋巴结分期的趋势(纵隔镜检查2005;超声检查2011年,uN2和总生存率,并比较整个组和临床淋巴结分期(cN)1{\textendash}3例有或无浸润分期患者的预后。结果侵袭性淋巴结分期从2005年的26\%增加到2017年的40\% (p <0.01)。超声内窥镜检查从2011年的19\%上升到2017年的32\% (p\<0.01),纵隔镜检查从2011年的24\%下降到2017年的21\% (p=0.08)。尽管有这些变化,uN2多年来一直稳定在8.7%。pN1患者的5年总生存率为41\%,而单淋巴结uN2患者的5年总生存率为37\% (p=0.18),多于一个淋巴结uN2患者的5年总生存率为26\% (p <0.01)。有创分期的cN1 3患者的5年总生存率为44 %,而无创分期的患者的5年总生存率为39 % (p=0.12)。Conclusion A significant increase in invasive mediastinal nodal staging in patients with resectable NSCLC was found between 2011 and 2017 in the Netherlands. Increasing use of less invasive endosonography prior to (or as a substitute for) surgical staging did not lead to more cases of uN2. Performance of invasive staging indicated a possible overall survival benefit in patients with cN1{\textendash}3 disease.Invasive mediastinal nodal staging of patients with resectable NSCLC significantly increased over the years in the Netherlands. Performance of invasive staging led to a possible overall survival benefit in patients with clinical N1{\textendash}3 disease. https://bit.ly/2S9Adaa}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/57/4/2001549}, eprint = {//www.qdcxjkg.com/content/57/4/2001549.full.pdf}, journal = {European Respiratory Journal} }