ty -jour t1-肺外结节病的临床表型：对法国，多种族，多中心队列JF的分析 - 欧洲呼吸杂志- Lhote, Raphael AU - Annesi-Maesano, Isabella AU - Nunes, Hilario AU - Launay, David AU - Borie, Raphael AU - Sacré, Karim AU - Schleinitz, Nicolas AU - Hamidou, Mohamed AU - Mahevas, Matthieu AU - Devilliers,HervéAu -Bonniaud，Philippe au -Lhote，FrançoisAu -Haroche，Julien Au -Rufat，Pierre au -amoura -Zahir au -Zahir au -Valeyre，Dominique Au -Cohen Au -Cohen Aubart，Fleur Y1- Y1-2021/04/01 ur -http：//01/04/01 ur- Http：// http：// http：//www.qdcxjkg.com/content/57/4/4/2001160.Abstract N2-结节病是一种罕见的疾病，出现了未知原因，在临床特征和结果中具有广泛的异质性。我们的目的是探索结节型表型及其临床相关性，特别是对肺外亚组的关注。结节病的流行病学（EPICARC）研究是一项法国回顾性多中心研究。根据标准化方案，在2013年至2016年之间，使用来自11个医院中心的适当代码通过国家住院记录确定了结节病患者。审查了医疗图表。结节病的表型是使用分层群集分析定义的。总共包括1237例患者（562名男性和675名女性）。结节病的平均年龄为43.5±13岁。分层聚类分析根据器官受累，疾病类型和症状确定了五种不同的表型：1）红斑肿瘤，关节受累和肺淋巴结淋巴结（n = 180）；2）眼睛，神经，消化和肾脏受累（n = 137）； 3) pulmonary involvement with fibrosis and heart involvement (n=630); 4) lupus pernio and a high percentage of severe involvement (n=41); and 5) hepatosplenic, peripheral lymph node and bone involvement (n=249). Phenotype 1 was associated with being European/Caucasian and female and with non-manual work, phenotype 2 with being European/Caucasian, and phenotypes 3 and 5 with being non-European/Caucasian. The labour worker proportion was significantly lower in phenotype 5 than in the other phenotypes.This multicentre study confirms the existence of distinct phenotypes of sarcoidosis, with a non-random distribution of organ involvement. These phenotypes differ according to sex, geographical origin and socioprofessional category.There are five distinct phenotypes of sarcoidosis, with a non-random distribution of organ involvement. These five phenotypes differ according to sex, geographical origin and socioprofessional category. https://bit.ly/3iCurZK ER -