TY - JOUR T1 -肺外结节病的临床表型:法国的分析,多民族、多中心队列JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01160 -2020欧元六世- 57 - 4 SP - 2001160盟利霍,拉斐尔AU - Annesi-Maesano,伊莎贝拉AU - Nunes,希拉里奥盟——Launay大卫盟——Borie拉斐尔盟——减少,卡里姆盟——Schleinitz尼古拉斯盟——HamidouMohamed AU - Mahevas, Matthieu AU - Devilliers, Hervé AU - Bonniaud, Philippe AU - Lhote, François AU - Haroche, Julien AU - Rufat, Pierre AU - amura, Zahir AU - Valeyre, Dominique AU - Cohen Aubart，Fleur Y1 - 2011/04/01 UR - //www.qdcxjkg.com/content/57/4/2001160.abstract N2 -结节病是一种病因不明的罕见疾病，临床特征和预后具有广泛的异质性。我们的目的是探讨结节病的表型及其与肺外亚群的临床相关性。结节病流行病学(EpiSarc)研究是一项法国回顾性多中心研究。结节病患者是通过2013年至2016年11个医院中心的适当代码，通过全国住院记录确定的，这些代码符合一项标准化协议。检查了病历。结节病的表型是用层次聚类分析来定义的。共纳入1237名患者(562名男性和675名女性)。结节病诊断的平均年龄为43.5±13岁。层次聚类分析根据脏器受累、疾病类型和症状确定了5种不同的表型:1)结节性红斑、关节受累和肺门淋巴结(n=180); 2) eye, neurological, digestive and kidney involvement (n=137); 3) pulmonary involvement with fibrosis and heart involvement (n=630); 4) lupus pernio and a high percentage of severe involvement (n=41); and 5) hepatosplenic, peripheral lymph node and bone involvement (n=249). Phenotype 1 was associated with being European/Caucasian and female and with non-manual work, phenotype 2 with being European/Caucasian, and phenotypes 3 and 5 with being non-European/Caucasian. The labour worker proportion was significantly lower in phenotype 5 than in the other phenotypes.This multicentre study confirms the existence of distinct phenotypes of sarcoidosis, with a non-random distribution of organ involvement. These phenotypes differ according to sex, geographical origin and socioprofessional category.There are five distinct phenotypes of sarcoidosis, with a non-random distribution of organ involvement. These five phenotypes differ according to sex, geographical origin and socioprofessional category. https://bit.ly/3iCurZK ER -