％0刊杂志百分之一，Raphael％Annesi-maesano，伊莎贝拉％A Nunes，Hilario％A Launay，David％A Borie，Raphael％aSacré，karim％a schleinitz，尼古拉斯％a hamidou，mohamed％a mahevas，Matthieu％漏洞，Hervé％Bonniaud，Philippe％A Haroche，François％Harche，Julien％A Rufat，Pierre％A valeye，Zahir％A Valeyre，Dominique％A Cohen Aubart，Fleur％T临床表型的肺外结节病：分析法国，多期族，多期中心队列％D 2021％R 10.1183 / 13993003.01160-2020％J欧洲呼吸期轴颈％p 2001160％v 57％n 4％x结节病是一种罕见的异质性未知原因的罕见疾病临床特征和结果。我们旨在探讨结节病表型及其临床关联，特别注意肺外亚组。结节病（EPISARC）研究的流行病学是法国回顾性的多期面研究。根据标准化议定书，通过使用2013年和2016年在2013年和2016年间的11家医院中心的适当代码通过国家住院记录来确定结节病患者。审查了医疗图表。使用分层聚类分析定义了结节病的表型。包括1237名患者（562名男性和675名妇女）。结节病的平均年龄诊断为43.5±13岁。等级聚类分析根据器官受累和疾病类型和症状确定了五种不同的表型：1）红斑节细胞膜，关节受累和肝淋巴结（n = 180）; 2) eye, neurological, digestive and kidney involvement (n=137); 3) pulmonary involvement with fibrosis and heart involvement (n=630); 4) lupus pernio and a high percentage of severe involvement (n=41); and 5) hepatosplenic, peripheral lymph node and bone involvement (n=249). Phenotype 1 was associated with being European/Caucasian and female and with non-manual work, phenotype 2 with being European/Caucasian, and phenotypes 3 and 5 with being non-European/Caucasian. The labour worker proportion was significantly lower in phenotype 5 than in the other phenotypes.This multicentre study confirms the existence of distinct phenotypes of sarcoidosis, with a non-random distribution of organ involvement. These phenotypes differ according to sex, geographical origin and socioprofessional category.There are five distinct phenotypes of sarcoidosis, with a non-random distribution of organ involvement. These five phenotypes differ according to sex, geographical origin and socioprofessional category. https://bit.ly/3iCurZK %U //www.qdcxjkg.com/content/erj/57/4/2001160.full.pdf