TY -的T1 CILP1右心室不适应的生物标志物在肺动脉高压JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01192 -2019欧元六世- 57 - 4 SP - 1901192 AU Keranov斯坦尼斯拉夫AU -多尔,奥利弗AU -贾法里,雷力盟——Troidl基督教非盟- Liebetrau Christoph AU - Kriechbaum,Steffen AU -凯勒,直到非盟-沃斯,桑德拉AU -鲍尔,蒂姆AU -洛伦兹,Jakob AU -里希特,曼努埃尔·j . AU - Tello Khodr AU -胆,亨宁非盟- Ghofrani·侯赛因·a . AU - Mayer,埃克哈特·盟——Wiedenroth Christoph b . AU -古思,Stefan盟——Lorchner Holger盟立杆,Jochen盟——Chelladurai Prakash盟——Pullamsetti索尼岛上AU -布劳恩Thomas AU - Seeger, Werner AU - Hamm, Christian W. AU - Nef，Holger Y1 - 2021/04/01 UR - //www.qdcxjkg.com/content/57/4/1901192.abstract N2 -我们的研究的目的是分析软骨中间层的蛋白表达蛋白1 (CILP)小鼠模型的右心室(RV)压力过载和评估CILP1心脏生物标志物的改造和适应不良的房车功能肺动脉高压(PH)患者。14只小鼠进行肺动脉带束术;另外9只老鼠接受了假手术。Western blotting和免疫染色分析所有心脏中CILP1蛋白的表达。在161例患者中(97例由PH引起的适应性和不适应性右心室压力超载;25例左室肥厚; 20 with dilative cardiomyopathy (DCM); 19 controls without LV or RV abnormalities)In mice, the amount of RV CILP1 was markedly higher after banding than after sham. Control patients had lower CILP1 serum levels than all other groups (p<0.001). CILP1 concentrations were higher in PH patients with maladaptive RV function than those with adaptive RV function (p<0.001), LV pressure overload (p<0.001) and DCM (p=0.003). CILP1 showed good predictive power for maladaptive RV in receiver operating characteristic analysis (area under the curve (AUC) 0.79). There was no significant difference between the AUCs of CILP1 and N-terminal pro-brain natriuretic peptide (NT-proBNP) (AUC 0.82). High CILP1 (cut-off value for maladaptive RV of ≥4373 pg·mL−1) was associated with lower tricuspid annular plane excursion/pulmonary artery systolic pressure ratios (p<0.001) and higher NT-proBNP levels (p<0.001).CILP1 is a novel biomarker of RV and LV pathological remodelling that is associated with RV maladaptation and ventriculoarterial uncoupling in patients with PH.CILP1 is a novel biomarker of RV and LV pathological remodelling that is associated with RV maladaptation and ventriculoarterial uncoupling in patients with pulmonary hypertension https://bit.ly/33HwLtN ER -