RT轴颈文章SR电子T1 CILP1作为肺动脉高压右心室治疗的生物标志物JF欧洲呼吸期刊JO EUR RESPIR J FD欧洲呼吸学会SP 1901192 DO 10.1183 / 13993003.01192-2019 VO 57是4 A1 Keranov，Stanislav A1dörr，Oliver A1188bet官网地址贾法里，雷利A1 Troidl，基督教A1 Liebetrau，克里斯托弗A1 Kriechbaum，斯特芬A1凯勒，直到A1沃斯，桑德拉A1鲍尔，蒂姆A1洛伦茨雅各布A1里克特，曼努埃尔J. A1特洛，Khodr A1瘿，亨宁A1 Ghofrani，侯赛因甲。A1 Mayer，Eckhard A1 Wiedenroth，Christoph B. A1 Guth，StefanA1Pöling，Jochen A1 Chelladurai，Prakash A1 Pullamsetti，Soni Savai A1 Braun，Thomas A1 Seeger，Werner A1 Hamm，Christian W. A1 Nef，HolgerYR 2021 ul //www.qdcxjkg.com/content/57/4/1901192.abstract ab我们的研究目的是分析右心室的小鼠模型中软骨中间层蛋白（cilp）1的蛋白质表达（RV）压力过载并评估CILP1作为心脏重塑的生物标志物和肺动脉高压患者（pH）。在14只小鼠中进行了肺动脉高压（pH）的患者的患者。另有九鼠涉及假手术。使用蛋白质印迹和免疫染色，在所有心脏中分析CILP1蛋白表达。在161名患者中测量CILP1血清浓度（97例，由pH值引起的，用左心室（LV）肥大引起的适应性和适应性的RV压力过载; 20患有扩张性心肌病（DCM）; 19个对小鼠没有LV或RV异常的对照组）绑带后RV CILP1的量显着高于假后。 Control patients had lower CILP1 serum levels than all other groups (p<0.001). CILP1 concentrations were higher in PH patients with maladaptive RV function than those with adaptive RV function (p<0.001), LV pressure overload (p<0.001) and DCM (p=0.003). CILP1 showed good predictive power for maladaptive RV in receiver operating characteristic analysis (area under the curve (AUC) 0.79). There was no significant difference between the AUCs of CILP1 and N-terminal pro-brain natriuretic peptide (NT-proBNP) (AUC 0.82). High CILP1 (cut-off value for maladaptive RV of ≥4373 pg·mL−1) was associated with lower tricuspid annular plane excursion/pulmonary artery systolic pressure ratios (p<0.001) and higher NT-proBNP levels (p<0.001).CILP1 is a novel biomarker of RV and LV pathological remodelling that is associated with RV maladaptation and ventriculoarterial uncoupling in patients with PH.CILP1 is a novel biomarker of RV and LV pathological remodelling that is associated with RV maladaptation and ventriculoarterial uncoupling in patients with pulmonary hypertension https://bit.ly/33HwLtN