TY -的T1 CILP1右心室不适应的生物标志物在肺动脉高压JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01192 -2019欧元六世- 57 - 4 SP - 1901192 AU Keranov斯坦尼斯拉夫AU -多尔,奥利弗AU -贾法里,雷力盟——Troidl基督教非盟- Liebetrau Christoph盟——Kriechbaum Steffen AU -凯勒,直到非盟-沃斯,桑德拉AU -鲍尔,蒂姆AU -洛伦兹,Jakob AU -里希特,曼努埃尔·J . AU - Tello Khodr AU -胆,亨宁非盟- Ghofrani·侯赛因·a . AU - Mayer,埃克哈特·盟——Wiedenroth Christoph b . AU -古思,Stefan盟——Lorchner Holger盟立杆,Jochen盟——Chelladurai Prakash盟——Pullamsetti索尼岛上AU -布劳恩,托马斯•AU -西格沃纳AU -哈姆,基督教w . AU, Nef Holger Y1 - 2021/04/01 UR - //www.qdcxjkg.com/content/57/4/1901192.abstract N2 -我们的研究的目的是分析蛋白质表达软骨中间层(CILP) 1右心室(RV)小鼠模型的压力过载和评估CILP1心脏生物标志物的改造和适应不良的房车功能患者的肺动脉高压(PH)。肺动脉条带进行了14个老鼠;另外九个老鼠接受虚假的手术。CILP1蛋白表达分析在所有的心用免疫印迹和免疫染色。CILP1血清浓度测定161例(97自适应和不适应的房车压力超负荷引起的PH值;25与左心室(LV)肥大;20与膨胀的心肌病(DCM);19个控件没有LV和房车异常)小鼠,房车的后分班后明显高于CILP1骗局。控制患者CILP1血清水平低于其他群体(术中,0.001)。CILP1浓度高PH值适应不良的患者比自适应RV房车功能函数(术中,0.001),LV压力过载(术中,0.001)和DCM (p = 0.003)。CILP1显示良好的预测能力不适应的房车在接受者操作特征分析(曲线下的面积(AUC) 0.79)。 There was no significant difference between the AUCs of CILP1 and N-terminal pro-brain natriuretic peptide (NT-proBNP) (AUC 0.82). High CILP1 (cut-off value for maladaptive RV of ≥4373 pg·mL−1) was associated with lower tricuspid annular plane excursion/pulmonary artery systolic pressure ratios (p<0.001) and higher NT-proBNP levels (p<0.001).CILP1 is a novel biomarker of RV and LV pathological remodelling that is associated with RV maladaptation and ventriculoarterial uncoupling in patients with PH.CILP1 is a novel biomarker of RV and LV pathological remodelling that is associated with RV maladaptation and ventriculoarterial uncoupling in patients with pulmonary hypertension https://bit.ly/33HwLtN ER -