PT -期刊文章盟Keranov斯坦尼斯拉夫AU -多尔,奥利弗AU -贾法里,雷力盟——Troidl基督教非盟- Liebetrau Christoph盟——Kriechbaum Steffen AU -凯勒,直到非盟-沃斯,桑德拉AU -鲍尔,蒂姆AU -洛伦兹,Jakob AU -里希特,曼努埃尔·j . AU - Tello Khodr AU -胆,亨宁非盟- Ghofrani·侯赛因·a . AU -迈耶Eckhard AU - Wiedenroth, Christoph B. AU - Guth, Stefan AU - Lörchner, Holger AU - Pöling, Jochen AU - Chelladurai, Prakash AU - Pullamsetti, Soni Savai AU - Braun, Thomas AU - Seeger, Werner AU - Hamm, Christian W. AU - Nef，Holger TI - CILP1右心室不适应的生物标志物在肺动脉高压的援助- 10.1183/13993003.01192 -2019 DP - 2021年4月01 TA -欧洲呼吸杂志》第六PG - 1901192 - 57 IP - 4 4099 - //www.qdcxjkg.com/content/57/4/1901192.short 4100 - //www.qdcxjkg.com/content/57/4/1901192.full所以欧元和J2021Apr 01; 57 AB - The aim of our study was to analyse the protein expression of cartilage intermediate layer protein (CILP)1 in a mouse model of right ventricular (RV) pressure overload and to evaluate CILP1 as a biomarker of cardiac remodelling and maladaptive RV function in patients with pulmonary hypertension (PH).Pulmonary artery banding was performed in 14 mice; another nine mice underwent sham surgery. CILP1 protein expression was analysed in all hearts using Western blotting and immunostaining. CILP1 serum concentrations were measured in 161 patients (97 with adaptive and maladaptive RV pressure overload caused by PH; 25 with left ventricular (LV) hypertrophy; 20 with dilative cardiomyopathy (DCM); 19 controls without LV or RV abnormalities)In mice, the amount of RV CILP1 was markedly higher after banding than after sham. Control patients had lower CILP1 serum levels than all other groups (p<0.001). CILP1 concentrations were higher in PH patients with maladaptive RV function than those with adaptive RV function (p<0.001), LV pressure overload (p<0.001) and DCM (p=0.003). CILP1 showed good predictive power for maladaptive RV in receiver operating characteristic analysis (area under the curve (AUC) 0.79). There was no significant difference between the AUCs of CILP1 and N-terminal pro-brain natriuretic peptide (NT-proBNP) (AUC 0.82). High CILP1 (cut-off value for maladaptive RV of ≥4373 pg·mL−1) was associated with lower tricuspid annular plane excursion/pulmonary artery systolic pressure ratios (p<0.001) and higher NT-proBNP levels (p<0.001).CILP1 is a novel biomarker of RV and LV pathological remodelling that is associated with RV maladaptation and ventriculoarterial uncoupling in patients with PH.CILP1 is a novel biomarker of RV and LV pathological remodelling that is associated with RV maladaptation and ventriculoarterial uncoupling in patients with pulmonary hypertension https://bit.ly/33HwLtN