% 0期刊文章% Keranov,斯坦尼斯拉夫%多尔,奥利弗%贾法里,雷力% Troidl,基督教% Liebetrau, Christoph % Kriechbaum,史蒂芬%凯勒,直到%沃斯,桑德拉%鲍尔,蒂姆%洛伦茨,Jakob %级,曼努埃尔·J . % Tello, Khodr %瘿,亨宁% Ghofrani,侯赛因·A . % Mayer,埃克哈特·% Wiedenroth, Christoph b %古思,Stefan % Lorchner, Holger %立杆,约% Chelladurai,普拉卡什% Pullamsetti,索尼岛上%布劳恩,托马斯%西格,Werner %哈姆,基督教w . % Nef Holger % T CILP1右心室不适应的生物标志物在肺动脉高压% D J 2021% R 10.1183/13993003.01192 -2019%欧洲呼吸杂志% P 1901192 % V 57% N 4% X,我们的研究目的是分析软骨中间层的蛋白表达蛋白1 (CILP)小鼠模型的右心室(RV)压力过载和评估CILP1心脏生物标志物的改造和适应不良的房车功能患者的肺动脉高压(PH)。肺动脉条带进行了14个老鼠;另外九个老鼠接受虚假的手术。CILP1蛋白表达分析在所有的心用免疫印迹和免疫染色。CILP1血清浓度测定161例(97自适应和不适应的房车压力超负荷引起的PH值;25与左心室(LV)肥大;20与膨胀的心肌病(DCM);19个控件没有LV和房车异常)小鼠,房车的后分班后明显高于CILP1骗局。控制患者CILP1血清水平低于其他组(p < 0.001)。CILP1浓度高PH患者适应不良的房车功能比自适应房车功能(p < 0.001), LV压力过载(p < 0.001)和DCM (p = 0.003)。CILP1显示良好的预测能力不适应的房车在接受者操作特征分析(曲线下的面积(AUC) 0.79)。 There was no significant difference between the AUCs of CILP1 and N-terminal pro-brain natriuretic peptide (NT-proBNP) (AUC 0.82). High CILP1 (cut-off value for maladaptive RV of ≥4373 pg·mL−1) was associated with lower tricuspid annular plane excursion/pulmonary artery systolic pressure ratios (p<0.001) and higher NT-proBNP levels (p<0.001).CILP1 is a novel biomarker of RV and LV pathological remodelling that is associated with RV maladaptation and ventriculoarterial uncoupling in patients with PH.CILP1 is a novel biomarker of RV and LV pathological remodelling that is associated with RV maladaptation and ventriculoarterial uncoupling in patients with pulmonary hypertension https://bit.ly/33HwLtN %U //www.qdcxjkg.com/content/erj/57/4/1901192.full.pdf