作者@article {Keranov1901192 = {Keranov,斯坦尼斯拉夫和D {\ " o} rr,奥利弗和贾法里,雷力Troidl,基督教和Liebetrau Christoph Kriechbaum,史蒂芬·凯勒,直到和沃斯,桑德拉·鲍尔,蒂姆和洛伦茨,雅克布里希特,曼努埃尔·j .和Tello Khodr瘿,亨宁Ghofrani,侯赛因·a·迈耶,埃克哈特·Wiedenroth, Christoph b和古思,斯蒂芬和L {\ " o} rchner Holger和P{\”阿凌},Jochen Chelladurai,普拉卡什和Pullamsetti索尼岛上和布劳恩,托马斯和西格,沃纳和哈姆,基督教w, Nef Holger}, title = {CILP1右心室不适应的生物标志物在肺动脉高压},体积= {57},number = {4}， location-id = {1901192}， year = {2021}， doi = {10.1183/13993003.01192-2019}， publisher ={欧洲188bet官网地址呼吸学会}，我们研究的目的是分析右心室(RV)压力过载小鼠模型中软骨中间层蛋白(CILP)1的蛋白表达，并评价CILP1作为肺动脉高压(PH)患者心脏重塑和右心室功能不适应的生物标志物。14只小鼠进行肺动脉束带;另外9只老鼠接受了假手术。使用Western blotting和免疫染色分析所有心脏中CILP1蛋白的表达。测量161例患者的CILP1血清浓度(97例因PH引起适应和不适应右心室压力超负荷;左室肥厚25例;扩张性心肌病(DCM) 20例;在小鼠中，右心室CILP1的数量在绑扎后明显高于假手术后。 Control patients had lower CILP1 serum levels than all other groups (p\<0.001). CILP1 concentrations were higher in PH patients with maladaptive RV function than those with adaptive RV function (p\<0.001), LV pressure overload (p\<0.001) and DCM (p=0.003). CILP1 showed good predictive power for maladaptive RV in receiver operating characteristic analysis (area under the curve (AUC) 0.79). There was no significant difference between the AUCs of CILP1 and N-terminal pro-brain natriuretic peptide (NT-proBNP) (AUC 0.82). High CILP1 (cut-off value for maladaptive RV of >=4373 pg{\textperiodcentered}mL-1) was associated with lower tricuspid annular plane excursion/pulmonary artery systolic pressure ratios (p\<0.001) and higher NT-proBNP levels (p\<0.001).CILP1 is a novel biomarker of RV and LV pathological remodelling that is associated with RV maladaptation and ventriculoarterial uncoupling in patients with PH.CILP1 is a novel biomarker of RV and LV pathological remodelling that is associated with RV maladaptation and ventriculoarterial uncoupling in patients with pulmonary hypertension https://bit.ly/33HwLtN}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/57/4/1901192}, eprint = {//www.qdcxjkg.com/content/57/4/1901192.full.pdf}, journal = {European Respiratory Journal} }