PT - JOURNAL ARTICLE AU - Pascoe, Christopher D. AU - Jha, Aruni AU - Ryu, Min Hyung AU - Ragheb, Mirna AU - Vaghasiya, Jignesh AU - Basu, Sujata AU - Stelmack, Gerald L. AU - Srinathan, Sadeesh AU- Kidane，Biniam au- Kindrachuk，Jason Au -O'Byrne，Paul M. Au -Gauvreau，Gail M. Au -Au -Ravandi -Ravandi，Amir au -Carlsten，Christopher Au -halayko，Andrew J. Ti- Andregen J. Ti-过敏性吸收产生了促炎性症与气道功能障碍辅助辅助相关的氧化磷脂酰胆碱-10.1183/13993003.00839-2020 DP -2021 FEB 01 TA-欧洲呼吸杂志PG -2000839 VI -57 IP -24099 -24099 -//www.qdcxjkg.com/erj.erjournals.com/57/57/2/2/2/2000839.Short 4100 -http：//www.qdcxjkg.com/content/57/2/2000839.full so -eur Respir J2021 Feb 01;57 AB-氧化磷脂酰胆碱（OXPC）是在氧化应激升高的条件下产生的，可以有助于人类疾病病理学。但是，它们在过敏性哮喘中的作用尚未开发。这项研究的目的是在气道高反应性（AHR）或轻度哮喘的人的过敏原挑战之后，在气道中表征OXPC的特征。还必须确定OXPC有助于与哮喘相关的病理生物学的能力。使用两个人类同类的支气管肺泡灌洗液，使用超高性能液相色谱串联质谱法对OXPC物种进行了定量。鼠薄切割肺切片用于测量由OXPC引起的气道狭窄。人类气道平滑肌（HASM）细胞暴露于OXPC中，以评估炎症表型的浓度相关的变化和信号网络的激活。气道中有和没有AHR的人之间的OXPC剖面有所不同，并且没有AHR和没有AHR的人，并且与甲基酚的反应性相关。暴露于过敏原的轻度哮喘患者会产生与晚期哮喘反应严重程度有关的独特OXPC特征。 OxPCs dose-dependently induced 15% airway narrowing in murine thin-cut lung slices. In HASM cells, OxPCs dose-dependently increased the biosynthesis of cyclooxygenase-2, interleukin (IL)-6, IL-8, granulocyte−macrophage colony-stimulating factor and the production of oxylipins via protein kinase C-dependent pathways.Data from human cohorts and primary HASM cell culture show that OxPCs are present in the airways, increase after allergen challenge and correlate with metrics of airway dysfunction. Furthermore, OxPCs may contribute to asthma pathobiology by promoting airway narrowing and inducing a pro-inflammatory phenotype and contraction of airway smooth muscle. OxPCs represent a potential novel target for treating oxidative stress-associated pathobiology in asthma.Unique profiles of oxidised phospholipids in the human lung correlate with airway pathophysiology. They are novel pro-inflammatory mediators with direct effects in structural cells via complex pathways, and are not targeted by standard asthma therapies. https://bit.ly/34UO2AL