TY -的T1减轻可变性的增加multiple breath washout indices due to tidal breathing JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.02765-2020 VL - 57 IS - 2 SP - 2002765 AU - Verbanck, Sylvia AU - Schuermans, Daniel AU - Paiva, Manuel AU - Robinson, Paul D. AU - Vanderhelst, Eef Y1 - 2021/02/01 UR - //www.qdcxjkg.com/content/57/2/2002765.abstract N2 - Multiple breath washout (MBW) tests have gained interest for clinical use, with normal values being published for the lung clearance index (LCI) in the paediatric [1, 2] and adult range [3, 4]. In adults, the greater interest in mechanisms of acinar and conductive ventilation heterogeneity (reflected in Sacin and Scond, respectively) drove the adoption of a 1 L breathing protocol to ensure a clear estimate of phase III slope. Alternatively, natural breathing protocols aimed to enhance feasibility in paediatric settings [5] have also been used in some adult studies [6].By studying tidal volume dependence of diagnostic multiple breath washout (MBW) indices, it can be determined how breathing patterns can be modulated to obtain less variable MBW outcomes and shorten MBW test duration in the clinical routine https://bit.ly/32GxRWj ER -