TY - T1的单细胞测序识别巨噬细胞RNA转录异物肉芽肿疾病JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.03794 -2020欧元SP - 2003794 AU廖Shu-Yi盟——爱,谢赫m . AU -模具,喀拉海盟——哥尼斯堡,伊恩•r . AU - Fu,瑞盟-戴维森,伊丽莎白AU -李,李盟——Fontenot Andrew p . AU -迈尔,丽莎·a . AU -杨,Ivana V. Y1 - 2011/01/01 UR - //www.qdcxjkg.com/content/early/2021/02/11/13993003.03794-2020.abstract N2 -结节病和慢性铍病(chronic beryl铍disease, CBD)都是肉芽肿性疾病，临床特征有重叠，但临床病程不同。CBD可能有缓慢的临床进展，很少消退，而结节病有不同的进展，可能消退取决于疾病[1]的阶段。这些共性和差异意味着抗原的差异，以及可能的清除和持久性。肺泡巨噬细胞在这一过程中发挥重要作用，驱动先天[2]和适应性免疫应答[3]。此外，巨噬细胞亚群可能促进肉芽肿炎症和肺损伤[4]的溶解，这是结节病和CBD的关键方面。利用单细胞RNA测序(scRNA-seq)，我们探索了进行性(SarcP)和缓和性(SarcR)结节病以及CBD和结节病之间的共同和独特的通路，重点关注巨噬细胞和巨噬细胞亚群(招募和留用)。脚注:这份手稿最近已被《欧洲呼吸杂志》接受发表。在我们的制作团队进行编辑和排版之前，它以可接受的形式在这里出版。在这些生产过程完成后，作者已经批准了结果证明，这篇文章将移到最新一期的ERJ在线。请打开或下载PDF来查看这篇文章。Conflict of interest: Dr. Lindner has nothing to disclose.Conflict of Interest: Dr. Liao has nothing to disclose.Conflict of Interest: Dr. Atif has nothing to disclose.Conflict of Interest: Dr. Mould has nothing to disclose.Conflict of Interest: Dr. Konigsberg has nothing to disclose.Conflict of Interest: Dr. Fu has nothing to disclose.Conflict of Interest: Dr. Davidson has nothing to disclose.Conflict of Interest: Dr. Li has nothing to disclose.Conflict of Interest: Dr. Fontenot reports grants from National Institutes of Health (NIH), during the conduct of the study.Conflict of Interest: Dr. Maier reports grants from National Institutes of Health, during the conduct of the study; grants from National Institutes of Health, grants from University of Cincinnati under a Mallinckrodt Foundation, grants from MNK14344100, grants from ATYR1923-C-002, outside the submitted work; and Dr. Maier is a member of the FSR Scientific Advisory Board. She does not receive any compensation for this activity.Conflict of Interest: Dr. Yang reports grants from NIH, during the conduct of the study and personal fees from Eleven P15, outside the submitted work. In addition, Dr. Yang has a patent Circulating Biomarkers of Preclinical Pulmonary Fibrosis pending. ER -