TY -的T1 -单细胞测序identifi RNAes macrophage transcriptional heterogeneities in granulomatous diseases JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.03794-2020 SP - 2003794 AU - Liao, Shu-Yi AU - Atif, Shaikh M. AU - Mould, Kara AU - Konigsberg, Iain R. AU - Fu, Rui AU - Davidson, Elizabeth AU - Li, Li AU - Fontenot, Andrew P. AU - Maier, Lisa A. AU - Yang, Ivana V. Y1 - 2021/01/01 UR - //www.qdcxjkg.com/content/early/2021/02/11/13993003.03794-2020.abstract N2 - Both sarcoidosis and chronic beryllium disease (CBD) are granulomatous diseases with overlapping clinical features, however, their clinical courses differ. CBD may have slow clinical progression and rarely resolves while sarcoidosis has variable progression and may resolve depending on the stage of the disease [1]. These commonalities and differences imply differences in antigen(s), and potentially clearance and persistence. Alveolar macrophages play an important role in this process driving innate [2] and adaptive immune responses [3]. Furthermore, subpopulations of macrophages may promote granulomatous inflammation and resolution of lung injury [4], key aspects of sarcoidosis and CBD. Using single-cell RNA sequencing (scRNA-seq), we explored the common and unique pathways between progressive (SarcP) and remitting (SarcR) sarcoidosis as well as CBD and sarcoidosis, focusing on macrophages and macrophages subpopulations (recruited versus resident).FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Lindner has nothing to disclose.Conflict of Interest: Dr. Liao has nothing to disclose.Conflict of Interest: Dr. Atif has nothing to disclose.Conflict of Interest: Dr. Mould has nothing to disclose.Conflict of Interest: Dr. Konigsberg has nothing to disclose.Conflict of Interest: Dr. Fu has nothing to disclose.Conflict of Interest: Dr. Davidson has nothing to disclose.Conflict of Interest: Dr. Li has nothing to disclose.Conflict of Interest: Dr. Fontenot reports grants from National Institutes of Health (NIH), during the conduct of the study.Conflict of Interest: Dr. Maier reports grants from National Institutes of Health, during the conduct of the study; grants from National Institutes of Health, grants from University of Cincinnati under a Mallinckrodt Foundation, grants from MNK14344100, grants from ATYR1923-C-002, outside the submitted work; and Dr. Maier is a member of the FSR Scientific Advisory Board. She does not receive any compensation for this activity.Conflict of Interest: Dr. Yang reports grants from NIH, during the conduct of the study and personal fees from Eleven P15, outside the submitted work. In addition, Dr. Yang has a patent Circulating Biomarkers of Preclinical Pulmonary Fibrosis pending. ER -