TY - T1的甲氨蝶呤和陆ng: Dr Jekyll and Mr Hyde JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00079-2021 VL - 57 IS - 2 SP - 2100079 AU - Cottin, Vincent AU - Bendstrup, Elisabeth AU - Bonniaud, Philippe AU - Nasser, Mouhamad AU - Spagnolo, Paolo AU - Valenzuela, Claudia AU - Kolb, Martin Y1 - 2021/02/01 UR - //www.qdcxjkg.com/content/57/2/2100079.abstract N2 - Involvement of the respiratory system, the commonest extra-articular manifestation of rheumatoid arthritis (RA), occurs to some extent in a large proportion of patients with RA. Any of the pulmonary compartments can be affected, either secondary to RA itself, or in relation to drug toxicity or opportunistic infection [1]. RA-associated interstitial lung disease (RA-ILD) is an increasingly recognised complication of RA, in many ways similar to idiopathic pulmonary fibrosis [2]. Clinically relevant RA-ILD may be present in up to 10% of patients with RA, and is associated with significant morbidity and mortality [1, 3], with no optimal treatment determined.Methotrexate can induce subacute hypersensitivity pneumonitis, a potentially lethal condition that should lead to drug discontinuation; however, its use does not seem to be associated with increased risk of chronic fibrosing ILD in rheumatoid arthritis https://bit.ly/3sCyjji ER -