TY - T1的甲氨蝶呤和风湿性关节炎相关的间质性肺病JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00337 -2020欧元六世- 57 - 2 SP - 2000337 AU Juge Pierre-Antoine AU -李,乔伊斯s . AU -刘,杰西卡盟——Kawano-Dourado Leticia AU -罗哈斯Serrano Jorge AU -塞巴斯蒂亚尼,马可盟科,Gouri盟——Matteson埃里克AU -邦飞利,卡琳娜盟——Sawamura Marcio盟——Kairalla罗纳尔多盟——Cavagna洛伦佐AU - Bozzalla Cassione,埃盟——曼Andreina盟——Mejia Mayra AU - Rodriguez-Henriquez,佩德罗AU - Gonzalez-Perez,蒙特塞拉特。非盟- Falfan-Valencia兰姆克非盟- Buendia-Roldan,Ivette AU - Perez-Rubio,格洛丽亚盟——原发、以斯帖盟——Gazal史蒂文盟——Borie拉斐尔盟——Ottaviani Sebastien盟——Kannengiesser卡罗琳盟——Wallaert Benoit盟——Uzunhan Yurdagul AU - Nunes,希拉里奥盟——Valeyre多米尼克盟——Saidenberg-Kermanac是什么,娜塔莉盟——Boissier Marie-Christophe盟——Wemeau-Stervinou Lidwine盟——FlipoRene-Marc盟——Marchand-Adam Sylvain盟——Richette帕斯卡盟——Allanore亚尼克AU -德龙,克莱尔盟——Truchetet Marie-Elise AU - Richez,克利斯朵夫盟——Schaeverbeke蒂埃里盟——Liote告诉妻子拉贝勒盟——Thabut Gabriel AU -迪恩,凯文·d . AU -所罗门,约书亚j . AU -多伊尔,特雷西AU - Ryu,杰伊·h . AU -罗萨斯,伊万盟——挖洞者,V. Michael AU - Boileau, Catherine AU - Debray, Marie-Pierre AU - Porcher, Raphaël AU - Schwartz, David A. AU - Vassallo, Robert AU - Crestani, Bruno AU - Dieudé，甲氨蝶呤(MTX)是类风湿性关节炎(RA)治疗的关键锚定药物。纤维化间质性肺疾病(ILD)是类风湿性关节炎的常见并发症。甲氨蝶呤暴露是否会增加类风湿性关节炎患者发生ILD的风险尚存争议。我们旨在评估既往使用甲氨蝶呤与RA-ILD的关系。方法通过病例对照研究设计，研究了410例伴有RA (RA-ILD)的慢性纤维化性ILD患者和673例无ILD的RA患者中MTX暴露与ILD的相关性。 Estimates were pooled over the different samples using meta-analysis techniques.Results Analysis of the discovery sample revealed an inverse relationship between MTX exposure and RA-ILD (adjusted OR 0.46, 95% CI 0.24–0.90; p=0.022), which was confirmed in the replication samples (pooled adjusted OR 0.39, 95% CI 0.19–0.79; p=0.009). The combined estimate using both the derivation and validation samples revealed an adjusted OR of 0.43 (95% CI 0.26–0.69; p=0.0006). MTX ever-users were less frequent among patients with RA-ILD compared to those without ILD, irrespective of chest high-resolution computed tomography pattern. In patients with RA-ILD, ILD detection was significantly delayed in MTX ever-users compared to never-users (11.4±10.4 years and 4.0±7.4 years, respectively; p<0.001).Answer to the question Our results suggest that MTX use is not associated with an increased risk of RA-ILD in patients with RA, and that ILD was detected later in MTX-treated patients.This multi-ethnic case–control study showed that methotrexate use is not associated with an increased risk of interstitial lung disease in patients with rheumatoid arthritis https://bit.ly/3fC8skd ER -