TY - JOUR T1 -肺功能&心血管病一项两样本孟德尔随机化研究JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.03196-2020 SP - 2003196詹姆斯·w·Y1 - 2021/01/01 UR - //www.qdcxjkg.com/content/early/2021/01/28/13993003.03196 - 2020. -抽象N2 -背景的观测研究表明减少肺功能与冠心病和缺血性中风的风险,独立的共享心血管危险因素如吸烟。我们使用最新的遗传流行病学方法来确定肺功能受损是否与心血管疾病风险增加有因果关系。方法和发现孟德尔随机化使用遗传变异作为工具变量来调查因果关系。初步分析使用两个样本孟德尔随机化肺功能单核苷酸多态性。为了避免对撞机偏差，主要分析使用了来自UKBiobank的肺功能单核苷酸多态性，该多变量孟德尔随机模型适用于身高、体重指数和吸烟。多变量孟德尔随机化研究显示，FVC降低导致冠状动脉疾病风险增加的有力证据，优势比:1.32(1.19 - 1.46)/标准差。FEV1的降低不太可能导致冠状动脉疾病风险的增加，因为在适应身高1.08(0.89,1.30)后，其作用的证据变得微弱。没有足够的证据表明肺功能下降会增加缺血性中风的风险。结论有强有力的证据表明，FVC降低与冠状动脉疾病是独立和因果相关的。 Although the mechanism remains unclear, FVC could be taken into consideration when assessing cardiovascular risk and considered a potential target for reducing cardiovascular events. FEV1 and airflow obstruction do not appear to cause increased cardiovascular events, confounding and collider bias may explain previous findings of a causal association.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Kohli has nothing to disclose.Conflict of interest: Dr. Higbee has nothing to disclose.Conflict of interest: Dr. Granell has nothing to disclose.Conflict of interest: Dr. Sanderson has nothing to disclose.Conflict of interest: Prof. Davey Smith has nothing to disclose.Conflict of interest: Dr. Dodd has nothing to disclose. ER -