@article {Higbee2003196，作者= {Higbee, Daniel H. and Granell, Raquel and Sanderson, Eleanor and Davey Smith, George and Dodd, James W.}，标题={肺功能&心血管疾病。两个样本孟德尔随机研究},elocation-id = {2003196} = {2021}, doi ={10.1183/13993003.03196 -2020},出版商={欧洲呼吸学会},文摘={背景的观测研究表明,减少肺功能与冠心病和缺血性中风的风险,独立的共享心188bet官网地址血管危险因素如吸烟。我们使用最新的遗传流行病学方法来确定肺功能受损是否与心血管疾病风险增加有因果关系。方法和发现孟德尔随机化使用遗传变异作为工具变量来调查因果关系。初步分析使用了两个样本孟德尔随机化肺功能单核苷酸多态性。为了避免碰撞偏差，主要的分析使用了从UKBiobank中确定的单核苷酸多态性肺功能，这是一个多变量孟德尔随机模型，条件是身高、体重指数和吸烟。多变量孟德尔随机化显示强有力的证据表明，减少FVC导致冠心病风险增加，每标准差的优势比为1{{textperiodcentered}32 (1{textperiodcentered}19{texttendash}1{textperiodcentered}46)。FEV1降低不太可能引起冠状动脉疾病的风险增加，因为在高度为1{{textperiodcentered}08 (0{{textperiodcentered}89, 1{{textperiodcentered}30)的条件下，其影响的证据变得微弱。没有足够的证据表明肺功能降低会增加缺血性中风的风险。结论有力证据表明FVC降低与冠状动脉疾病有独立的因果关系。虽然机制尚不清楚，但在评估心血管风险时可以考虑FVC，并将其视为减少心血管事件的潜在目标。 FEV1 and airflow obstruction do not appear to cause increased cardiovascular events, confounding and collider bias may explain previous findings of a causal association.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Kohli has nothing to disclose.Conflict of interest: Dr. Higbee has nothing to disclose.Conflict of interest: Dr. Granell has nothing to disclose.Conflict of interest: Dr. Sanderson has nothing to disclose.Conflict of interest: Prof. Davey Smith has nothing to disclose.Conflict of interest: Dr. Dodd has nothing to disclose.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/early/2021/01/28/13993003.03196-2020}, eprint = {//www.qdcxjkg.com/content/early/2021/01/28/13993003.03196-2020.full.pdf}, journal = {European Respiratory Journal} }