TY - T1的骨质疏松症的发病率和脆弱性骨折哮喘:英国摩根富林明匹配以人群为基础的群组研究-欧洲呼吸杂志》乔和J - 10.1183/13993003.01251 -2020欧元六世- 57 - 1 SP - 2001251 AU Chalitsios Christos诉AU - McKeever特里西娅m . AU -肖,多明尼克大肠Y1 - 2021/01/01 UR - //www.qdcxjkg.com/content/57/1/2001251.abstract N2 -介绍骨质疏松和脆弱性骨折与糖皮质激素的主要治疗哮喘;然而,这些骨骼并发症在哮喘需要更好的描述。方法进行匹配的队列研究使用英国临床实践研究数据库(CPRD)。成人哮喘事件代码被识别和匹配,有多达四个随机选择的人没有哮喘,按照年龄、性别和实践。骨质疏松症和脆弱性骨折发病率计算,Cox回归进行比较风险率。我们报告的影响,年龄、性别、糖皮质激素和特定的骨折的风险。结果哮喘患者骨质疏松的风险更高(调整风险比(aHR) 1.18, 95% CI 1.13 - -1.23)和12% (aHR 1.12, 95%可信区间1.07 - -1.16)比一般人更容易维持脆性骨折。年龄修改了哮喘对骨质疏松的影响和脆弱性骨折,这样效果更强的年轻人(pinteraction< 0.0001)。气道高反应性脊椎(1.40,95% CI 1.33 - -1.48)和前臂/手腕(aHR 1.27, 95% CI 1.22 - -1.32)的网站与一个更大的发病率。剂量反应关系观察口服糖皮质激素(OCS)和骨质疏松症,而脆性骨折的风险增加商务课程每年有六个或更多。 Regular use of inhaled corticosteroids (ICS) increased the risk of both bone conditions.Conclusions Patients with asthma are more likely to develop osteoporosis or sustain fragility fractures than the general population, with a particular concern in younger people and those more frequently using OCS and ICS.Patients with asthma are more likely to develop osteoporosis or sustain fragility fractures than the general population, with a particular concern in younger people and those more frequently using OCS or ICS https://bit.ly/2D8cjbm ER -