TY - JOUR T1 - Identification of asthma phenotypes based on extrapulmonary treatable traits JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00240-2020 VL - 57 IS - 1 SP - 2000240 AU - Freitas, Patricia Duarte AU - Xavier,RafaellaFrançaAu -McDonald，Vanessa Marie Au -Gibson，Peter Gerard au -Cordova -Rivera，Laura au -Furlanetto -Furlanetto，Karina Couto au -de Oliveira -de Oliveira，Joice Mara Au -Carvalho Pinto，Regina Maria au -Cukier，Alberto，Alberto，Carvalho au -carvalho，Rafael au- Carvalho，Celso Ricardo Fernandes Y1-2021/01/01 Ur -http：//www.qdcxjkg.com/content.com/content/57/1/1/2000240.Abstract N2- Asthma是一种异构和复杂的疾病，以及一种异质和复杂疾病，先前尚未报告基于可肺外治疗性状的哮喘表型。这项研究的目的是识别和表征基于中等至属性哮喘参与者的临床，功能，人类和心理特征的簇。部分多中心涉及巴西和澳大利亚中心的研究。与中度至重度哮喘的参与者（n = 296）被连续招募。评估了体育活动和久坐时间，临床哮喘控制，人体测量数据，肺功能以及心理和健康状况。参与者通过分层群集分析对参与者进行分类，并使用ANOVA，KRUSKAL – WALLIS和卡方检验进行了比较。进行了多个逻辑和线性回归模型，以评估变量之间的关联。我们确定了四个群集：1）患有受控哮喘的参与者；2）患有不受控制的哮喘的参与者身体不活跃，更久坐；3）患有哮喘和低身体活动的参与者，他们也肥胖，经历了焦虑和/或抑郁症状； and 4) participants with very uncontrolled asthma who were physically inactive, more sedentary, obese and experienced anxiety and/or depression symptoms. Higher levels of sedentary time, female sex and anxiety symptoms were associated with increased odds of exacerbation risk, while being more active showed a protective factor for hospitalisation. Asthma control was associated with sex, the occurrence of exacerbation, physical activity and health status.Physical inactivity, obesity and symptoms of anxiety and/or depression were associated with worse asthma outcomes, and closely and inextricably associated with asthma control. This cluster analysis highlights the importance of assessing extrapulmonary traits to improve personalised management and outcomes for people with moderate and severe asthma.Cluster analysis based on extrapulmonary treatable traits in people with moderate-to-severe asthma indicates that physical inactivity, higher levels of sedentary time, symptoms of anxiety and depression, and obesity are associated with worse outcomes. https://bit.ly/2ATv1Ce ER -