RT期刊文章SR电子T1框架用于评估结核病感染JF欧洲呼吸杂志Jo EUR Respir J FD欧洲呼吸学会SP 2004078 Do 10.1183 / 13993003.04078-2020 A1 Hamada，Yohhei A1 Den Boon，Saskia A1 Maria Cirillo，Dani188bet官网地址elaA1 Penn-Nicholson，Adam A1 Ruhwald，Morten A1 Oxlade，Dick A1 Oxlade，Dennis A1 kanchar，Avinash A1 Korobitsyn，Alexei A1 Zignol，Alberto A1 Kasaeva，Tereza YR 2021 UL http：// Erj.ERSJOURNALS.com / CONTET /早期/ 2021/04 / 13993003.04078-2020.ABSTRACT AB的结核病（TB）预防性待遇（TPT）必须加速，以实现联合国高级别所设定的目标会议结核病和结束结核病策略。有效的TPT的扩大率受到对运营挑战的担忧阻碍了实施Tb感染的现有测试。新的更简单的测试可以促进TB感染的测试扩大。我们提出了一种评估新的免疫因素试验来检测Tb感染的框架，旨在促进其标准化评估，并加快通过全球和国家政策和随后的扩展。该框架描述了在评估TB感染的新测试时要考虑的原则，并为制造商，研究人员，监管机构和其他用户提供指导，研究设计，人口，参考标准，样本量计算和数据分析，并且它也与全球相一致世界卫生组织在2020年通过的结核病研究与创新战略。我们还简要介绍了在评估新测试时应考虑的技术问题，包括皮肤测试的安全性，患者和卫生系统患者产生的费用以及运营特征.Footnotesthis手稿最近被接受在欧洲呼吸期刊上出版。它在汇款和排版的抄本之前在此处发布于其已接受的表单。在这些生产过程完成后，作者已批准所产生的证据，这篇文章将转入最新问题ERJ Online。 Please open or download the PDF to view this article.Conflict of interest: Dr. Hamada has nothing to disclose.Conflict of interest: Dr. Den Boon has nothing to disclose.Conflict of interest: Dr. Cirillo has nothing to disclose.Conflict of interest: Dr. Penn-Nicholson reports grants and non-financial support from multiple partners, during the conduct of the study; In addition, Dr. Penn-Nicholson has a patent WO2016123058A1 WIPO (PCT): Biomarkers for detection of tuberculosis risk. 2016-08-04 pending, and a patent WO2017081618A9 WIPO (PCT): Biomarkers for prospective determination of risk for development of active tuberculosis. 2017-07-13 pending.Conflict of interest: Dr. Ruhwald reports grants and non-financial support from multiple, during the conduct of the study; In addition, Dr. Ruhwald has a patent WO2017084671A1 issued to Statens Serum Institute, and a patent O2008028489A2 issued to Statens Serum Institute.Conflict of interest: Dr. menzies has nothing to disclose.Conflict of interest: Dr. Oxlade has nothing to disclose.Conflict of interest: Dr. Falzon has nothing to disclose.Conflict of interest: Dr. Kanchar has nothing to disclose.Conflict of interest: Dr. Korobitsyn has nothing to disclose.Conflict of interest: Dr. Zignol has nothing to disclose.Conflict of interest: Dr. Matteelli has nothing to disclose.Conflict of interest: Dr. Kasaeva has nothing to disclose.