TY - JOUR T1 -睡眠相关呼吸障碍和肺高压JF -欧洲呼吸杂志JO - Eur Respir J DO - 10.1183/13993003.02258-2020 VL - 57 IS - 1 SP - 2002258 AU - Adir, Yochai AU - Humbert, Marc AU - Chaouat, Ari Y1 - 201/01/01 UR - //www.qdcxjkg.com/content/57/1/2002258.abstract N2 -睡眠相关呼吸障碍(sdd)包括阻塞性呼吸暂停、中枢性呼吸暂停和睡眠相关低通气。这些夜间活动有可能增加睡眠时的肺动脉压(PAP)，也有可能在清醒状态下增加。“纯”阻塞性睡眠呼吸暂停综合征(OSAS)是PAP轻微增加的原因，其临床影响尚未得到证实。相比之下，在肥胖低通气综合征(OHS)或重叠综合征(慢性阻塞性肺疾病(COPD)与阻塞性睡眠呼吸暂停(OSA)的关联)中，夜间呼吸事件有助于肺高压(PH)的发展，这通常是严重的。在后一种情况下，为了改善肺血流动力学，sbd的治疗是必不可少的。肺动脉高压(PAH)或慢性血栓栓塞性肺动脉高压(CTEPH)患者有发生sbd的风险。在睡眠中可以观察到阻塞性和中枢性呼吸暂停，以及呼吸灌注不匹配的恶化。在这样的患者群体中，应该强烈怀疑sbd;然而，睡眠研究的精确指示和记录的类型仍有待明确。PAH或cteh患者的OSAS诊断应鼓励使用持续气道正压(CPAP)治疗。 The presence of isolated nocturnal hypoxaemia should also prompt the initiation of long-term oxygen therapy. These treatments are likely to avoid worsening of PH; however, it is prudent not to treat central apnoea and Cheyne–Stokes respiration (CSR) with adaptive servo-ventilation in patients with chronic right-heart failure because of a potential risk of serious adverse effects from such treatment.In this review we will consider the current knowledge of the consequences of SBDs on pulmonary haemodynamics in patients with and without chronic respiratory disease (group 3 of the clinical classification of PH) and the effect of treatments of respiratory events during sleep on PH. The prevalence and consequences of SBDs in PAH and CTEPH (groups 1 and 4 of the clinical classification of PH, respectively), as well as therapeutic options, will also be discussed.In some clinical situations, important to identify, sleep-related breathing disorders can be responsible for severe pulmonary haemodynamic consequences. In these situations, it is important to treat apnoeas, hypopnoeas and nocturnal oxygen desaturations. https://bit.ly/30akkoM ER -