ty -jour t1-呼气呼吸分析通过使用Enose技术:间质性肺部病JF的新型诊断工具JF-欧洲呼吸杂志JO -EUR RESSIR J DO -10.1183/13993003.02042-2020 VL -57 IS -1 SP -2002042 AU--2002042 AU--2002042 AU-- 2002042 AU--2002042 AU--2002042Moor,Catharina C. Au -Oppenheimer,Judith C. Au -Nakshbandi,Gizal au -Aurs,Joachim G.J.V.Au -Brinkman,Paul au -Maitland -Van der Zee,Anke -Hilse au -Wijsenbeek,Marlies S. Y1-2021/01/01 UR -//www.qdcxjkg.com/content/57/1/2002042。摘要N2-引入间质肺疾病(ILD)的早期和准确诊断仍然是一个主要挑战。急需更好的非侵入性诊断工具。我们的目的是使用ENES技术来评估呼气呼吸分析的准确性,以区分ILD患者和健康对照,并区分ILD子组。在这项横断面研究中,使用ENESE Technology进行了呼出的连续ILD患者的呼气和健康对照的呼气。(螺旋龙)。使用部分最小二平方判别分析和接收器操作特征分析进行统计分析。在较大的子组中使用了独立的训练和验证集(2:1)。总共包括322名ILD患者和48个健康对照:结节病(n = 141),特发性肺纤维化(IPF)(ipf)(n = 85),结缔组织,结缔组织组织疾病相关的ILD(n = 33),慢性超敏性肺炎(n = 25),特发性非特异性间质性肺炎(n = 10),间质性肺炎,具有自身免疫性特征(n = 11)和其他ILDS(n = 17)。在训练和验证集中,启用了ILD和健康对照区域区分的传感器,曲线(AUC)为1.00。 Comparison of patients with IPF and patients with other ILDs yielded an AUC of 0.91 (95% CI 0.85–0.96) in the training set and an AUC of 0.87 (95% CI 0.77–0.96) in the validation set. The eNose reliably distinguished between individual diseases, with AUC values ranging from 0.85 to 0.99.Conclusions eNose technology can completely distinguish ILD patients from healthy controls and can accurately discriminate between different ILD subgroups. Hence, exhaled breath analysis using eNose technology could be a novel biomarker in ILD, enabling timely diagnosis in the future.Exhaled breath analysis using eNose technology can accurately discriminate between different ILD subgroups and individual diseases. eNose technology could be a novel diagnostic tool in ILD, enabling timely diagnosis in the future. https://bit.ly/3jJs2hf ER -