TY - T1的扩散能力异常患者一氧化碳COVID-19在3个月的随访JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.03677 -2020欧元SP - 2003677 AU秦魏盟——陈,施盟——张选手盟——咚,分盟,张朱盟——胡Bingzhu盟——朱,紫阳AU -李,发久AU - Wang，小江AU - Wang，益民AU - Zhen，开元AU - Wang, Jing AU - Wan, YuLei AU - Li, Hongbo AU - Elalamy, Ismaïl AU - Li, Chenghong AU - Zhai, Zhenguo AU - Wang，陈Y1 - 2021/01/01 UR - //www.qdcxjkg.com/content/early/2020/12/17/13993003.03677 - 2020. -抽象N2 -客观评估肺功能和2019年冠状病毒病临床症状(COVID-19)幸存者出院后3个月内,和识别风险因素与肺功能受损有关。方法和材料对2020年1 - 2月中国武汉某医院出院后3个月的新冠肺炎患者进行前瞻性随访，检查肺功能及临床特征。结果共纳入647例患者。87例(13%)患者出现乏力，63例(10%)患者出现心悸，56例(9%)患者出现呼吸困难。这三种症状在重症患者中的患病率明显高于非重症患者(虚弱患者为19% vs . 10%， p=0.003;心悸为14%对7%，p=0.007;12%对7%的呼吸困难，p=0.014)。多变量回归结果显示重症患者(OR: 1.7, 95%CI: 1.1-2.6, p=0.026)或住院时间较长的患者(OR: 1.03, 95%CI: 1.00-1.05, p=0.041)持续症状的奇数增加。有81例患者肺功能检测结果，其中非重症41例，重症40例。在这个亚组中，44例(54%)患者表现出一氧化碳扩散能力(DLCO)异常(68%重度患者vs 42%非重度患者，p=0.019)。 Chest CT total severity score (TSS)>10.5 (OR: 10.4; 95%CI: 2.5–44.1; p=0.001) on admission and ARDS (OR: 4.6; 95%CI: 1.4–15.5; p=0.014) were significantly associated with impaired DLCO. Pulmonary interstitial damage may be associated with abnormal DLCO.Conclusion Pulmonary function, particularly DLCO, declined in COVID-19 survivors. This decrease was associated with TSS of chest CT >10.5 and ARDS occurrence. Pulmonary interstitial damage might contribute to the imparied DLCO.COVID-19 patients present with impaired DLCO at 90 days after discharge, particularly severe patients. Chest CT TSS >10.5 and ARDS occurrence are associated with impaired DLCO. Pulmonary interstitial damage may contribute to the impaired DLCO. ER -