儿童早期发育与7岁时的肺功能相关:未来的以人群为基础的研究摩根富林明欧洲呼吸杂志乔和J FD欧元欧洲呼吸学会SP 2000157 10.1183/13993003.00157 -2020签证官56是6 A1佩拉188bet官网地址尔塔,加芙A1 Abellan,艾丽西亚A1蒙塔泽里,Parisa A1 Basterrechea,米克尔A1 Esplugues,安娜A1 Gonzalez-Palacios,桑德拉A1又,塞丽娜A1 Santa-Marina,Loreto A1纽约州立大学,乔迪A1 Vrijheid,马蒂娜A1卡萨斯,马里A1 Garcia-Aymerich,朱迪思年2020 UL //www.qdcxjkg.com/content/56/6/2000157.abstract AB先前的研究有关产后早期增长与后来的肺功能是有限的,但是他们的解释方法来评估孩子的成长。我们的目的是评估儿童早期发育(通过4年的体重指数(BMI)轨迹测量)与7年的肺功能之间的关系。我们纳入了来自西班牙Infancia y Medio Ambiente以人口为基础的出生队列的1257名儿童。根据4年前通过潜在阶级增长分析确定的BMI轨迹，儿童早期成长被分为5类。这些轨迹在出生尺寸(“较低”、“平均”、“较高”)和BMI增长速度(“较低”、“较高”)方面存在差异。我们使用多变量混合回归，将这些轨迹与7年的肺功能(1秒用力呼气量(FEV1)、用力肺活量(FVC)、FEV1/FVC和用力呼气流量在FVC的25%-75% (FEF25-75%))联系起来。7岁时，与出生体重平均且体重指数增长缓慢的儿童相比，出生体重高且体重指数增长加快的儿童FVC % pred较高(3.3%，95% CI 1.0%-5.6%)， FEV1/FVC % pred较低(−1.5%，95% CI−2.9% -−0.1%)。在出生体重较低和体重指数增加加快的儿童中也观察到类似的关联。出生体重较低和BMI增长较慢的儿童7岁时FVC %较低。 No association was found for FEF25–75%.Independently of birth size, children with accelerated BMI gain in early childhood had higher lung function at 7 years but showed airflow limitation. Children with lower birth size and slower BMI gain in early childhood had lower lung function at 7 years.Independently of birth size, children with accelerated BMI gain in early childhood had higher lung function at 7 years but showed airflow limitation. Children with lower birth size and slower BMI gain in early childhood had lower lung function at 7 years. https://bit.ly/308ZDtn