PT -期刊文章AU -加纳，Justin L. AU - Shaipanich, Tawimas AU - Hartman, Jorine E. AU - Orton, Christopher M. AU - Caneja, Cielito AU - Klooster, Karin AU - Thornton, John AU - Sin, Don D. AU - Slebos, Dirk-Jan AU - Shah，Pallav L. TI -对慢性支气管炎慢性阻塞性肺疾病患者使用计量冷冻喷雾的前瞻性安全性和可行性研究AID - 10.1183/13993003.00556-2020 DP -2020年12月01日TA -欧洲呼吸杂志PG - 2000556 VI - 56 IP - 6 4099 - //www.qdcxjkg.com/content/56/6/2000556.short 4100 - //www.qdcxjkg.com/content/56/6/2000556.full SO - Eur Respir J2020 12月01日;目前没有批准的干预措施可以对抗慢性阻塞性肺疾病慢性支气管炎的气道化生和粘液高分泌。然而，计量冷冻喷雾(MCS)输送液氮到气管支气管气道消融异常上皮细胞，促进健康粘膜再生。本研究的目的是评价MCS治疗慢性支气管炎的可行性、有效性和安全性。方法选取1 s内用力呼气量在30-80%预测值的患者，并进行最佳药物治疗。主要结果为可行性(治疗完成)、有效性(圣乔治呼吸问卷(SGRQ) 3个月变化)和安全性(不良事件发生率)。次要结局为肺功能、运动能力和其他患者报告的结局。结果35例患者，男19例/女16例，年龄47-76岁，全球慢性阻塞性肺疾病倡议I级(n=3)， II级(n=10)， III级(n=22)，气管支气管树行交错液氮治疗。34例患者完成3个疗程，每疗程34.3±12.1 min，间隔4-6周; one withdrew after the first treatment. ∼1800 doses of MCS were delivered. Clinically meaningful improvements in patient-reported outcomes were observed at 3 months: change in SGRQ −6.4 (95% CI −11.4 to −1.3; p=0.01), COPD Assessment Test (CAT) −3.8 (95% CI −6.4 to −1.3; p<0.01) and Leicester Cough Questionnaire (LCQ) 21.6 (95% CI 7.3 to 35.9; p<0.01). Changes in CAT were durable to 6 months (−3.4, 95% CI −5.9 to −0.9; p=0.01); changes in SGRQ and LCQ were durable to 9 months (−6.9, 95% CI −13.0 to −0.9; p=0.03 and 13.4, 95% CI 2.1 to 24.6; p=0.02, respectively. At 12 months, 14 serious adverse events were recorded in 11 (31.4%) subjects; six (43%) moderate and eight (57%) severe. Nine were respiratory-related: six exacerbations of COPD, two pneumonias and one case of increased coughing; all recovered without sequelae. None were serious device- or procedure-related adverse events.Conclusion MCS is safe, feasible and associated with clinically meaningful improvements in multidimensional patient-reported outcomes.RejuvenAir system treatment for individuals with chronic bronchitis in COPD is safe, feasible, well tolerated, and resulted in clinically meaningful improvements in multidimensional measures of cough, sputum production, breathlessness and quality of life https://bit.ly/30KBfPs