@Article {Axelsson1902154，作者= {Akelsson，Gisli T.和Putman，Rachel K.和Aspelund，Thor和Gudmundsson，Elias F.和Hida，Tomayuki和Araaki，Tetsuro和Nishino，Mizuki和Hatabu，Hiroto和Gudnason，Viloto和Gudnason，Vilmundur和匈奴跳，加里M.和Gudmundsson，Gunnar}，标题= {间质肺异常与癌症诊断的关联}，体积= {56}，Number = {6}，Elocation-Id = {1902154}，年= {2020}，DOI = {10.1183 / 13993003.02154-2019}，出版商= {欧洲呼吸学会}188bet官网地址，摘要= {肺癌的发病率较高，患有特发性肺纤维化的患者众所周知。尚不清楚间质肺异常，即肺的早期纤维化变化是一般人群中肺癌的危险因素。研究{\ TextQuotight}目标是评估间质肺异常是否与诊断有关，和来自肺癌和其他癌症的死亡率。来自雷克雅未克研究的数据，使用了5764岁的冰岛成年人的队列。结果数据来自电子医疗记录。灰色{\ TextQuoteright} S试验，Cox比例危险模型和比例分布危险危险模型用于分析间质肺异常与肺癌诊断和肺癌死亡的关联以及所有癌症的诊断和死亡率。累积率更大肺癌诊断（P + <0.001）和肺癌死亡率（P + <0.001），与其他人的间质肺异常相比。间质肺异常与调整的COX模型中肺癌诊断（危害比率2.77）和肺癌死亡率（危险比2.89）的危害增加有关。在包括肺癌的模型中发现任何癌症异常的关联肺异常，但不包括排除肺癌的模型。具有间质肺异常的人数增加了肺癌和肺癌死亡率的风险，但不是其他癌症。 This implies that an association between fibrotic and neoplastic diseases of the lung exists from the early stages of lung fibrosis and suggests that interstitial lung abnormalities could be considered as a risk factor in lung cancer screening efforts.Interstitial lung abnormalities are associated with an increased hazard of lung cancer diagnosis and lung cancer mortality in a general population cohort. Cancers other than lung cancer were not associated with interstitial lung abnormalities. https://bit.ly/3hWdc6m}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/56/6/1902154}, eprint = {//www.qdcxjkg.com/content/56/6/1902154.full.pdf}, journal = {European Respiratory Journal} }